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Huntingtin Lowering Strategies for Disease Modification in Huntington’s Disease

Huntington’s disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold great promise. These include DNA-targeting techniques such as zinc-finger proteins, transcription activator-like effector nucleases, […]

Trainee Spotlight: Jeffy Rajan

Kudos to Jeffy Rajan, recipient of a 2019 Brain, Behaviour and Development (BB&D) Trainee Boost Award.  Jeffy hangs out in the Goldowitz Lab and her project is “Impact of motor learning performance in Developmental Coordination Disorder (DCD)”. “I am very grateful to be the recipient of the BB&D Trainee Boost Award in recognition of a […]