- Gettler, LT, Lin, DTS, Miegakanda, V, Lew-Levy, S, Eick, GN, Snodgrass, JJ et al.. Epigenetic aging in children from a small-scale farming society in The Congo Basin: Associations with child growth and family conflict. Dev Psychobiol. 2019; :. doi: 10.1002/dev.21935. PubMed PMID:31724171 .
- Aristizabal, MJ, Anreiter, I, Halldorsdottir, T, Odgers, CL, McDade, TW, Goldenberg, A et al.. Biological embedding of experience: A primer on epigenetics. Proc. Natl. Acad. Sci. U.S.A. 2019; :. doi: 10.1073/pnas.1820838116. PubMed PMID:31624126 .
- McEwen, LM, O'Donnell, KJ, McGill, MG, Edgar, RD, Jones, MJ, MacIsaac, JL et al.. The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells. Proc. Natl. Acad. Sci. U.S.A. 2019; :. doi: 10.1073/pnas.1820843116. PubMed PMID:31611402 .
- Clifford, RL, Patel, J, MacIsaac, JL, McEwen, LM, Johnson, SR, Shaw, D et al.. Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation. Sci Rep. 2019;9 (1):14409. doi: 10.1038/s41598-019-50873-y. PubMed PMID:31595000 PubMed Central PMC6783553.
- Solomon, O, Macisaac, JL, Tindula, G, Kobor, MS, Eskenazi, B, Holland, N et al.. 5-Hydroxymethylcytosine in cord blood and associations of DNA methylation with sex in newborns. Mutagenesis. 2019; :. doi: 10.1093/mutage/gez023. PubMed PMID:31587037 .
- Humphreys, KL, Moore, SR, Davis, EG, MacIsaac, JL, Lin, DTS, Kobor, MS et al.. DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis. Transl Psychiatry. 2019;9 (1):245. doi: 10.1038/s41398-019-0582-7. PubMed PMID:31582756 PubMed Central PMC6776528.
- Chang, EY, Tsai, S, Aristizabal, MJ, Wells, JP, Coulombe, Y, Busatto, FF et al.. MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts. Nat Commun. 2019;10 (1):4265. doi: 10.1038/s41467-019-12271-w. PubMed PMID:31537797 PubMed Central PMC6753070.
- Aristizabal, MJ, Dever, K, Negri, GL, Shen, M, Hawe, N, Benschop, JJ et al.. Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast. J. Biol. Chem. 2019;294 (44):16080-16094. doi: 10.1074/jbc.RA119.008515. PubMed PMID:31506296 PubMed Central PMC6827322.
- Fahy, GM, Brooke, RT, Watson, JP, Good, Z, Vasanawala, SS, Maecker, H et al.. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell. 2019;18 (6):e13028. doi: 10.1111/acel.13028. PubMed PMID:31496122 PubMed Central PMC6826138.
- Merrill, SM, Gladish, N, Kobor, MS. Social Environment and Epigenetics. Curr Top Behav Neurosci. 2019; :. doi: 10.1007/7854_2019_114. PubMed PMID:31485989 .
- Shen, Y, Grisdale, CJ, Islam, SA, Bose, P, Lever, J, Zhao, EY et al.. Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments. Proc. Natl. Acad. Sci. U.S.A. 2019;116 (38):19098-19108. doi: 10.1073/pnas.1813495116. PubMed PMID:31471491 PubMed Central PMC6754609.
- Sbihi, H, Jones, MJ, MacIsaac, JL, Brauer, M, Allen, RW, Sears, MR et al.. Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization. J. Allergy Clin. Immunol. 2019; :. doi: 10.1016/j.jaci.2019.07.047. PubMed PMID:31470034 .
- Gervin, K, Salas, LA, Bakulski, KM, van Zelm, MC, Koestler, DC, Wiencke, JK et al.. Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data. Clin Epigenetics. 2019;11 (1):125. doi: 10.1186/s13148-019-0717-y. PubMed PMID:31455416 PubMed Central PMC6712867.
- Badran, M, Yassin, BA, Lin, DTS, Kobor, MS, Ayas, N, Laher, I et al.. Gestational intermittent hypoxia induces endothelial dysfunction, reduces perivascular adiponectin and causes epigenetic changes in adult male offspring. J. Physiol. (Lond.). 2019;597 (22):5349-5364. doi: 10.1113/JP277936. PubMed PMID:31441069 .
- Letourneau, NL, de Koning, APJ, Sekhon, B, Ntanda, HN, Kobor, M, Deane, AJ et al.. Parenting Interacts With Plasticity Genes in Predicting Behavioral Outcomes in Preschoolers. Can J Nurs Res. 2019; :844562119863612. doi: 10.1177/0844562119863612. PubMed PMID:31403319 .
- Sundermann, EE, Hussain, MA, Moore, DJ, Horvath, S, Lin, DTS, Kobor, MS et al.. Inflammation-related genes are associated with epigenetic aging in HIV. J. Neurovirol. 2019; :. doi: 10.1007/s13365-019-00777-4. PubMed PMID:31286441 .
- Czamara, D, Eraslan, G, Page, CM, Lahti, J, Lahti-Pulkkinen, M, Hämäläinen, E et al.. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nat Commun. 2019;10 (1):2548. doi: 10.1038/s41467-019-10461-0. PubMed PMID:31186427 PubMed Central PMC6559955.
- Ong, ML, Tuan, TA, Poh, J, Teh, AL, Chen, L, Pan, H et al.. Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome. Genes Brain Behav. 2019;18 (7):e12576. doi: 10.1111/gbb.12576. PubMed PMID:31020763 .
- van Kuilenburg, ABP, Tarailo-Graovac, M, Richmond, PA, Drögemöller, BI, Pouladi, MA, Leen, R et al.. Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS. N. Engl. J. Med. 2019;380 (15):1433-1441. doi: 10.1056/NEJMoa1806627. PubMed PMID:30970188 .
- Hari Dass, SA, McCracken, K, Pokhvisneva, I, Chen, LM, Garg, E, Nguyen, TTT et al.. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine. 2019;42 :188-202. doi: 10.1016/j.ebiom.2019.03.051. PubMed PMID:30922963 PubMed Central PMC6491717.
- Toepfer, P, O'Donnell, KJ, Entringer, S, Heim, CM, Lin, DTS, MacIsaac, JL et al.. A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment. J Am Acad Child Adolesc Psychiatry. 2019;58 (12):1207-1216. doi: 10.1016/j.jaac.2019.03.006. PubMed PMID:30858011 PubMed Central PMC6733663.
- McDade, TW, Ryan, CP, Jones, MJ, Hoke, MK, Borja, J, Miller, GE et al.. Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood. Am. J. Phys. Anthropol. 2019;169 (1):3-11. doi: 10.1002/ajpa.23800. PubMed PMID:30771258 .
- Wu, Y, Lin, X, Lim, IY, Chen, L, Teh, AL, MacIsaac, JL et al.. Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm. Clin Epigenetics. 2019;11 (1):26. doi: 10.1186/s13148-018-0599-4. PubMed PMID:30744680 PubMed Central PMC6371604.
- Toepfer, P, O'Donnell, KJ, Entringer, S, Garg, E, Heim, CM, Lin, DTS et al.. Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness. Psychoneuroendocrinology. 2019;103 :156-162. doi: 10.1016/j.psyneuen.2019.01.013. PubMed PMID:30690225 PubMed Central PMC6554513.
- Brown, JAR, Kobor, MS. Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage. DNA Repair (Amst.). 2019;74 :1-16. doi: 10.1016/j.dnarep.2019.01.001. PubMed PMID:30639951 .
- Islam, SA, Goodman, SJ, MacIsaac, JL, Obradović, J, Barr, RG, Boyce, WT et al.. Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation. Epigenetics Chromatin. 2019;12 (1):1. doi: 10.1186/s13072-018-0245-6. PubMed PMID:30602389 PubMed Central PMC6314079.
- Lussier, AA, Bodnar, TS, Mingay, M, Morin, AM, Hirst, M, Kobor, MS et al.. Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues. Front Genet. 2018;9 :610. doi: 10.3389/fgene.2018.00610. PubMed PMID:30568673 PubMed Central PMC6290329.
- Husquin, LT, Rotival, M, Fagny, M, Quach, H, Zidane, N, McEwen, LM et al.. Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation. Genome Biol. 2018;19 (1):222. doi: 10.1186/s13059-018-1601-3. PubMed PMID:30563547 PubMed Central PMC6299574.
- Barha, CK, Salvante, KG, Jones, MJ, Farré, P, Blais, J, Kobor, MS et al.. Early post-conception maternal cortisol, children's HPAA activity and DNA methylation profiles. J Dev Orig Health Dis. 2019;10 (1):73-87. doi: 10.1017/S2040174418000880. PubMed PMID:30428949 .
- Bush, NR, Edgar, RD, Park, M, MacIsaac, JL, McEwen, LM, Adler, NE et al.. The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation. Epigenomics. 2018;10 (11):1445-1461. doi: 10.2217/epi-2018-0042. PubMed PMID:30351206 PubMed Central PMC6462839.
- McEwen, LM, Jones, MJ, Lin, DTS, Edgar, RD, Husquin, LT, MacIsaac, JL et al.. Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array. Clin Epigenetics. 2018;10 (1):123. doi: 10.1186/s13148-018-0556-2. PubMed PMID:30326963 PubMed Central PMC6192219.
- Roberts, AL, Gladish, N, Gatev, E, Jones, MJ, Chen, Y, MacIsaac, JL et al.. Exposure to childhood abuse is associated with human sperm DNA methylation. Transl Psychiatry. 2018;8 (1):194. doi: 10.1038/s41398-018-0252-1. PubMed PMID:30279435 PubMed Central PMC6168447.
- Lin, X, Tan, JYL, Teh, AL, Lim, IY, Liew, SJ, MacIsaac, JL et al.. Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types. Epigenetics. 2018;13 (9):941-958. doi: 10.1080/15592294.2018.1522929. PubMed PMID:30232931 PubMed Central PMC6284779.
- Goodman, SJ, Roubinov, DS, Bush, NR, Park, M, Farré, P, Emberly, E et al.. Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood. Dev Sci. 2019;22 (2):e12739. doi: 10.1111/desc.12739. PubMed PMID:30176105 PubMed Central PMC6433477.
- Chen, LM, Yao, N, Garg, E, Zhu, Y, Nguyen, TTT, Pokhvisneva, I et al.. PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores. BMC Bioinformatics. 2018;19 (1):295. doi: 10.1186/s12859-018-2289-9. PubMed PMID:30089455 PubMed Central PMC6083617.
- Moore, SR, Kobor, MS. Variability in DNA methylation at the serotonin transporter gene promoter: epigenetic mechanism or cell-type artifact?. Mol. Psychiatry. 2018; :. doi: 10.1038/s41380-018-0121-6. PubMed PMID:30082839 .
- Conradt, E, Adkins, DE, Crowell, SE, Monk, C, Kobor, MS. An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior. Dev. Psychopathol. 2018;30 (3):881-890. doi: 10.1017/S0954579418000688. PubMed PMID:30068429 PubMed Central PMC6074043.
- Garg, E, Chen, L, Nguyen, TTT, Pokhvisneva, I, Chen, LM, Unternaehrer, E et al.. The early care environment and DNA methylome variation in childhood. Dev. Psychopathol. 2018;30 (3):891-903. doi: 10.1017/S0954579418000627. PubMed PMID:30068421 .
- Solomon, O, MacIsaac, J, Quach, H, Tindula, G, Kobor, MS, Huen, K et al.. Comparison of DNA methylation measured by Illumina 450K and EPIC BeadChips in blood of newborns and 14-year-old children. Epigenetics. 2018;13 (6):655-664. doi: 10.1080/15592294.2018.1497386. PubMed PMID:30044683 PubMed Central PMC6140901.
- Ryan, CP, Hayes, MG, Lee, NR, McDade, TW, Jones, MJ, Kobor, MS et al.. Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women. Sci Rep. 2018;8 (1):11100. doi: 10.1038/s41598-018-29486-4. PubMed PMID:30038336 PubMed Central PMC6056536.
- Austin, MK, Chen, E, Ross, KM, McEwen, LM, Maclsaac, JL, Kobor, MS et al.. Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes. Psychoneuroendocrinology. 2018;97 :131-134. doi: 10.1016/j.psyneuen.2018.07.007. PubMed PMID:30016711 .
- Horvath, S, Stein, DJ, Phillips, N, Heany, SJ, Kobor, MS, Lin, DTS et al.. Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents. AIDS. 2018;32 (11):1465-1474. doi: 10.1097/QAD.0000000000001854. PubMed PMID:29746298 PubMed Central PMC6026068.
- Clifford, RL, Fishbane, N, Patel, J, MacIsaac, JL, McEwen, LM, Fisher, AJ et al.. Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD. Clin Epigenetics. 2018;10 :32. doi: 10.1186/s13148-018-0464-5. PubMed PMID:29527240 PubMed Central PMC5838860.
- Islam, SA, Lussier, AA, Kobor, MS. Epigenetic analysis of human postmortem brain tissue. Handb Clin Neurol. 2018;150 :237-261. doi: 10.1016/B978-0-444-63639-3.00017-7. PubMed PMID:29496144 .
- Forest, M, O'Donnell, KJ, Voisin, G, Gaudreau, H, MacIsaac, JL, McEwen, LM et al.. Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time. Epigenetics. 2018;13 (1):19-32. doi: 10.1080/15592294.2017.1411443. PubMed PMID:29381404 PubMed Central PMC5837078.
- Gonzalez, A, Catherine, N, Boyle, M, Jack, SM, Atkinson, L, Kobor, M et al.. Healthy Foundations Study: a randomised controlled trial to evaluate biological embedding of early-life experiences. BMJ Open. 2018;8 (1):e018915. doi: 10.1136/bmjopen-2017-018915. PubMed PMID:29374668 PubMed Central PMC5829768.
- Lussier, AA, Morin, AM, MacIsaac, JL, Salmon, J, Weinberg, J, Reynolds, JN et al.. DNA methylation as a predictor of fetal alcohol spectrum disorder. Clin Epigenetics. 2018;10 :5. doi: 10.1186/s13148-018-0439-6. PubMed PMID:29344313 PubMed Central PMC5767049.
- O'Donnell, KJ, Chen, L, MacIsaac, JL, McEwen, LM, Nguyen, T, Beckmann, K et al.. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Transl Psychiatry. 2018;8 (1):15. doi: 10.1038/s41398-017-0063-9. PubMed PMID:29317599 PubMed Central PMC5802588.
- Lin, X, Teh, AL, Chen, L, Lim, IY, Tan, PF, MacIsaac, JL et al.. Choice of surrogate tissue influences neonatal EWAS findings. BMC Med. 2017;15 (1):211. doi: 10.1186/s12916-017-0970-x. PubMed PMID:29202839 PubMed Central PMC5715509.
- Carja, O, MacIsaac, JL, Mah, SM, Henn, BM, Kobor, MS, Feldman, MW et al.. Worldwide patterns of human epigenetic variation. Nat Ecol Evol. 2017;1 (10):1577-1583. doi: 10.1038/s41559-017-0299-z. PubMed PMID:29185505 .
- Moore, SR, McEwen, LM, Quirt, J, Morin, A, Mah, SM, Barr, RG et al.. Epigenetic correlates of neonatal contact in humans. Dev. Psychopathol. 2017;29 (5):1517-1538. doi: 10.1017/S0954579417001213. PubMed PMID:29162165 .
- McEwen, LM, Gatev, EG, Jones, MJ, MacIsaac, JL, McAllister, MM, Goulding, RE et al.. DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial. Appl Physiol Nutr Metab. 2018;43 (3):233-239. doi: 10.1139/apnm-2017-0436. PubMed PMID:29049890 .
- Chang, EY, Novoa, CA, Aristizabal, MJ, Coulombe, Y, Segovia, R, Chaturvedi, R et al.. RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability. J. Cell Biol. 2017;216 (12):3991-4005. doi: 10.1083/jcb.201703168. PubMed PMID:29042409 PubMed Central PMC5716281.
- Jones, MJ, Moore, SR, Kobor, MS. Principles and Challenges of Applying Epigenetic Epidemiology to Psychology. Annu Rev Psychol. 2018;69 :459-485. doi: 10.1146/annurev-psych-122414-033653. PubMed PMID:29035689 .
- Verschoor, CP, McEwen, LM, Kobor, MS, Loeb, MB, Bowdish, DME. DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly. Exp. Gerontol. 2018;105 :47-52. doi: 10.1016/j.exger.2017.10.010. PubMed PMID:29032243 .
- McDade, TW, Jones, MJ, Miller, G, Borja, J, Kobor, MS, Kuzawa, CW et al.. Birth weight and postnatal microbial exposures predict the distribution of peripheral blood leukocyte subsets in young adults in the Philippines. J Dev Orig Health Dis. 2018;9 (2):198-207. doi: 10.1017/S2040174417000794. PubMed PMID:29017617 .
- Mang, CS, McEwen, LM, MacIsaac, JL, Snow, NJ, Campbell, KL, Kobor, MS et al.. Exploring genetic influences underlying acute aerobic exercise effects on motor learning. Sci Rep. 2017;7 (1):12123. doi: 10.1038/s41598-017-12422-3. PubMed PMID:28935933 PubMed Central PMC5608967.
- Davis, EG, Humphreys, KL, McEwen, LM, Sacchet, MD, Camacho, MC, MacIsaac, JL et al.. Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume. Transl Psychiatry. 2017;7 (8):e1223. doi: 10.1038/tp.2017.188. PubMed PMID:28850111 PubMed Central PMC5611751.
- Morin, AM, Gatev, E, McEwen, LM, MacIsaac, JL, Lin, DTS, Koen, N et al.. Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs. Clin Epigenetics. 2017;9 :75. doi: 10.1186/s13148-017-0370-2. PubMed PMID:28770015 PubMed Central PMC5526324.
- Edgar, RD, Jones, MJ, Meaney, MJ, Turecki, G, Kobor, MS. BECon: a tool for interpreting DNA methylation findings from blood in the context of brain. Transl Psychiatry. 2017;7 (8):e1187. doi: 10.1038/tp.2017.171. PubMed PMID:28763057 PubMed Central PMC5611738.
- North, ML, Jones, MJ, MacIsaac, JL, Morin, AM, Steacy, LM, Gregor, A et al.. Blood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit. Allergy. 2018;73 (1):196-205. doi: 10.1111/all.13263. PubMed PMID:28755526 .
- Brückmann, C, Islam, SA, MacIsaac, JL, Morin, AM, Karle, KN, Di Santo, A et al.. DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment. Sci Rep. 2017;7 (1):6605. doi: 10.1038/s41598-017-06847-z. PubMed PMID:28747766 PubMed Central PMC5529570.
- McDade, TW, Ryan, C, Jones, MJ, MacIsaac, JL, Morin, AM, Meyer, JM et al.. Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (29):7611-7616. doi: 10.1073/pnas.1620661114. PubMed PMID:28673994 PubMed Central PMC5530653.
- Verschoor, CP, McEwen, LM, Kohli, V, Wolfson, C, Bowdish, DM, Raina, P et al.. The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study. BMC Genet. 2017;18 (1):57. doi: 10.1186/s12863-017-0525-3. PubMed PMID:28637423 PubMed Central PMC5480116.
- Gopalan, S, Carja, O, Fagny, M, Patin, E, Myrick, JW, McEwen, LM et al.. Trends in DNA Methylation with Age Replicate Across Diverse Human Populations. Genetics. 2017;206 (3):1659-1674. doi: 10.1534/genetics.116.195594. PubMed PMID:28533441 PubMed Central PMC5500158.
- Girchenko, P, Lahti, J, Czamara, D, Knight, AK, Jones, MJ, Suarez, A et al.. Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth. Clin Epigenetics. 2017;9 :49. doi: 10.1186/s13148-017-0349-z. PubMed PMID:28503212 PubMed Central PMC5422977.
- Budinger, GRS, Kohanski, RA, Gan, W, Kobor, MS, Amaral, LA, Armanios, M et al.. The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J. Gerontol. A Biol. Sci. Med. Sci. 2017;72 (11):1492-1500. doi: 10.1093/gerona/glx090. PubMed PMID:28498894 PubMed Central PMC5861849.
- McEwen, LM, Morin, AM, Edgar, RD, MacIsaac, JL, Jones, MJ, Dow, WH et al.. Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region. Epigenetics Chromatin. 2017;10 :21. doi: 10.1186/s13072-017-0128-2. PubMed PMID:28465725 PubMed Central PMC5408416.
- Lin, X, Lim, IY, Wu, Y, Teh, AL, Chen, L, Aris, IM et al.. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Med. 2017;15 (1):50. doi: 10.1186/s12916-017-0800-1. PubMed PMID:28264723 PubMed Central PMC5340003.
- Leung, JM, Fishbane, N, Jones, M, Morin, A, Xu, S, Liu, JC et al.. Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion. Aging (Albany NY). 2017;9 (3):687-705. doi: 10.18632/aging.101184. PubMed PMID:28237978 PubMed Central PMC5391226.
- Lussier, AA, Weinberg, J, Kobor, MS. Epigenetics studies of fetal alcohol spectrum disorder: where are we now?. Epigenomics. 2017;9 (3):291-311. doi: 10.2217/epi-2016-0163. PubMed PMID:28234026 PubMed Central PMC5549650.
- Edgar, RD, Jones, MJ, Robinson, WP, Kobor, MS. An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs. Clin Epigenetics. 2017;9 :11. doi: 10.1186/s13148-017-0320-z. PubMed PMID:28184257 PubMed Central PMC5290610.
- Gref, A, Merid, SK, Gruzieva, O, Ballereau, S, Becker, A, Bellander, T et al.. Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up. Am. J. Respir. Crit. Care Med. 2017;195 (10):1373-1383. doi: 10.1164/rccm.201605-1026OC. PubMed PMID:27901618 PubMed Central PMC5443897.
- Steunou, AL, Cramet, M, Rossetto, D, Aristizabal, MJ, Lacoste, N, Drouin, S et al.. Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome. Mol. Cell. Biol. 2016;36 (22):2768-2781. doi: 10.1128/MCB.00112-16. PubMed PMID:27550811 PubMed Central PMC5086519.
- Esposito, EA, Jones, MJ, Doom, JR, MacIsaac, JL, Gunnar, MR, Kobor, MS et al.. Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity. Dev. Psychopathol. 2016;28 (4pt2):1385-1399. doi: 10.1017/S0954579416000055. PubMed PMID:26847422 PubMed Central PMC5903568.
- Horvath, S, Gurven, M, Levine, ME, Trumble, BC, Kaplan, H, Allayee, H et al.. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biol. 2016;17 (1):171. doi: 10.1186/s13059-016-1030-0. PubMed PMID:27511193 PubMed Central PMC4980791.
- Portales-Casamar, E, Lussier, AA, Jones, MJ, MacIsaac, JL, Edgar, RD, Mah, SM et al.. DNA methylation signature of human fetal alcohol spectrum disorder. Epigenetics Chromatin. 2016;9 :25. doi: 10.1186/s13072-016-0074-4. PubMed PMID:27358653 PubMed Central PMC4926300.
- Clifford, RL, Jones, MJ, MacIsaac, JL, McEwen, LM, Goodman, SJ, Mostafavi, S et al.. Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation. J. Allergy Clin. Immunol. 2017;139 (1):112-121. doi: 10.1016/j.jaci.2016.03.046. PubMed PMID:27321436 .
- Robert McMaster, W, Morrison, CJ, Kobor, MS. Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation. Trends Parasitol. 2016;32 (7):515-521. doi: 10.1016/j.pt.2016.04.002. PubMed PMID:27142564 .
- Aristizabal, MJ, Kobor, MS. A single flexible RNAPII-CTD integrates many different transcriptional programs. Transcription. 2016;7 (2):50-6. doi: 10.1080/21541264.2016.1163451. PubMed PMID:26985717 PubMed Central PMC4853039.
- Koestler, DC, Jones, MJ, Usset, J, Christensen, BC, Butler, RA, Kobor, MS et al.. Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL). BMC Bioinformatics. 2016;17 :120. doi: 10.1186/s12859-016-0943-7. PubMed PMID:26956433 PubMed Central PMC4782368.
- De Souza, RA, Islam, SA, McEwen, LM, Mathelier, A, Hill, A, Mah, SM et al.. DNA methylation profiling in human Huntington's disease brain. Hum. Mol. Genet. 2016;25 (10):2013-2030. doi: 10.1093/hmg/ddw076. PubMed PMID:26953320 .
- Buschdorf, JP, Ong, ML, Ong, SX, MacIsaac, JL, Chng, K, Kobor, MS et al.. Low birth weight associates with hippocampal gene expression. Neuroscience. 2016;318 :190-205. doi: 10.1016/j.neuroscience.2016.01.013. PubMed PMID:26791528 .
- Teh, AL, Pan, H, Lin, X, Lim, YI, Patro, CP, Cheong, CY et al.. Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples. Epigenetics. 2016;11 (1):36-48. doi: 10.1080/15592294.2015.1132136. PubMed PMID:26786415 PubMed Central PMC4846133.
- Leung, GP, Brown, JA, Glover, JN, Kobor, MS. Rtt107 BRCT domains act as a targeting module in the DNA damage response. DNA Repair (Amst.). 2016;37 :22-32. doi: 10.1016/j.dnarep.2015.10.007. PubMed PMID:26641499 .
- Fagny, M, Patin, E, MacIsaac, JL, Rotival, M, Flutre, T, Jones, MJ et al.. The epigenomic landscape of African rainforest hunter-gatherers and farmers. Nat Commun. 2015;6 :10047. doi: 10.1038/ncomms10047. PubMed PMID:26616214 PubMed Central PMC4674682.
- Oros Klein, K, Grinek, S, Bernatsky, S, Bouchard, L, Ciampi, A, Colmegna, I et al.. funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types. Bioinformatics. 2016;32 (4):593-5. doi: 10.1093/bioinformatics/btv615. PubMed PMID:26500152 PubMed Central PMC4743629.
- Aristizabal, MJ, Negri, GL, Kobor, MS. The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition. PLoS Genet. 2015;11 (10):e1005608. doi: 10.1371/journal.pgen.1005608. PubMed PMID:26496706 PubMed Central PMC4619828.
- Pacis, A, Tailleux, L, Morin, AM, Lambourne, J, MacIsaac, JL, Yotova, V et al.. Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. 2015;25 (12):1801-11. doi: 10.1101/gr.192005.115. PubMed PMID:26392366 PubMed Central PMC4665002.
- de Goede, OM, Razzaghian, HR, Price, EM, Jones, MJ, Kobor, MS, Robinson, WP et al.. Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells. Clin Epigenetics. 2015;7 :95. doi: 10.1186/s13148-015-0129-6. PubMed PMID:26366232 PubMed Central PMC4567832.
- Lussier, AA, Stepien, KA, Weinberg, J, Kobor, MS. Prenatal alcohol exposure alters gene expression in the rat brain: Experimental design and bioinformatic analysis of microarray data. Data Brief. 2015;4 :239-52. doi: 10.1016/j.dib.2015.05.007. PubMed PMID:26217797 PubMed Central PMC4510447.
- Jones, MJ, Islam, SA, Edgar, RD, Kobor, MS. Adjusting for Cell Type Composition in DNA Methylation Data Using a Regression-Based Approach. Methods Mol. Biol. 2017;1589 :99-106. doi: 10.1007/7651_2015_262. PubMed PMID:26126446 .
- Beery, AK, McEwen, LM, MacIsaac, JL, Francis, DD, Kobor, MS. Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Horm Behav. 2016;77 :42-52. doi: 10.1016/j.yhbeh.2015.05.022. PubMed PMID:26122287 PubMed Central PMC4691570.
- Subbarao, P, Anand, SS, Becker, AB, Befus, AD, Brauer, M, Brook, JR et al.. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax. 2015;70 (10):998-1000. doi: 10.1136/thoraxjnl-2015-207246. PubMed PMID:26069286 .
- Pan, H, Lin, X, Wu, Y, Chen, L, Teh, AL, Soh, SE et al.. HIF3A association with adiposity: the story begins before birth. Epigenomics. 2015;7 (6):937-50. doi: 10.2217/epi.15.45. PubMed PMID:26011824 PubMed Central PMC4863876.
- Farré, P, Jones, MJ, Meaney, MJ, Emberly, E, Turecki, G, Kobor, MS et al.. Concordant and discordant DNA methylation signatures of aging in human blood and brain. Epigenetics Chromatin. 2015;8 :19. doi: 10.1186/s13072-015-0011-y. PubMed PMID:25977707 PubMed Central PMC4430927.
- Jones, MJ, Goodman, SJ, Kobor, MS. DNA methylation and healthy human aging. Aging Cell. 2015;14 (6):924-32. doi: 10.1111/acel.12349. PubMed PMID:25913071 PubMed Central PMC4693469.
- Kaplow, IM, MacIsaac, JL, Mah, SM, McEwen, LM, Kobor, MS, Fraser, HB et al.. A pooling-based approach to mapping genetic variants associated with DNA methylation. Genome Res. 2015;25 (6):907-17. doi: 10.1101/gr.183749.114. PubMed PMID:25910490 PubMed Central PMC4448686.
- Gurnot, C, Martin-Subero, I, Mah, SM, Weikum, W, Goodman, SJ, Brain, U et al.. Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates. Epigenetics. 2015;10 (5):361-72. doi: 10.1080/15592294.2015.1026031. PubMed PMID:25891251 PubMed Central PMC4622680.
- Lussier, AA, Stepien, KA, Neumann, SM, Pavlidis, P, Kobor, MS, Weinberg, J et al.. Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain. Alcohol. Clin. Exp. Res. 2015;39 (2):251-61. doi: 10.1111/acer.12622. PubMed PMID:25684047 PubMed Central PMC4833439.