Michael Kobor Publications

  1. Gettler, LT, Lin, DTS, Miegakanda, V, Lew-Levy, S, Eick, GN, Snodgrass, JJ et al.. Epigenetic aging in children from a small-scale farming society in The Congo Basin: Associations with child growth and family conflict. Dev Psychobiol. 2019; :. doi: 10.1002/dev.21935. PubMed PMID:31724171 .
  2. Aristizabal, MJ, Anreiter, I, Halldorsdottir, T, Odgers, CL, McDade, TW, Goldenberg, A et al.. Biological embedding of experience: A primer on epigenetics. Proc. Natl. Acad. Sci. U.S.A. 2019; :. doi: 10.1073/pnas.1820838116. PubMed PMID:31624126 .
  3. McEwen, LM, O'Donnell, KJ, McGill, MG, Edgar, RD, Jones, MJ, MacIsaac, JL et al.. The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells. Proc. Natl. Acad. Sci. U.S.A. 2019; :. doi: 10.1073/pnas.1820843116. PubMed PMID:31611402 .
  4. Clifford, RL, Patel, J, MacIsaac, JL, McEwen, LM, Johnson, SR, Shaw, D et al.. Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation. Sci Rep. 2019;9 (1):14409. doi: 10.1038/s41598-019-50873-y. PubMed PMID:31595000 PubMed Central PMC6783553.
  5. Solomon, O, Macisaac, JL, Tindula, G, Kobor, MS, Eskenazi, B, Holland, N et al.. 5-Hydroxymethylcytosine in cord blood and associations of DNA methylation with sex in newborns. Mutagenesis. 2019; :. doi: 10.1093/mutage/gez023. PubMed PMID:31587037 .
  6. Humphreys, KL, Moore, SR, Davis, EG, MacIsaac, JL, Lin, DTS, Kobor, MS et al.. DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis. Transl Psychiatry. 2019;9 (1):245. doi: 10.1038/s41398-019-0582-7. PubMed PMID:31582756 PubMed Central PMC6776528.
  7. Chang, EY, Tsai, S, Aristizabal, MJ, Wells, JP, Coulombe, Y, Busatto, FF et al.. MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts. Nat Commun. 2019;10 (1):4265. doi: 10.1038/s41467-019-12271-w. PubMed PMID:31537797 PubMed Central PMC6753070.
  8. Aristizabal, MJ, Dever, K, Negri, GL, Shen, M, Hawe, N, Benschop, JJ et al.. Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast. J. Biol. Chem. 2019;294 (44):16080-16094. doi: 10.1074/jbc.RA119.008515. PubMed PMID:31506296 PubMed Central PMC6827322.
  9. Fahy, GM, Brooke, RT, Watson, JP, Good, Z, Vasanawala, SS, Maecker, H et al.. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell. 2019;18 (6):e13028. doi: 10.1111/acel.13028. PubMed PMID:31496122 PubMed Central PMC6826138.
  10. Merrill, SM, Gladish, N, Kobor, MS. Social Environment and Epigenetics. Curr Top Behav Neurosci. 2019; :. doi: 10.1007/7854_2019_114. PubMed PMID:31485989 .
  11. Shen, Y, Grisdale, CJ, Islam, SA, Bose, P, Lever, J, Zhao, EY et al.. Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments. Proc. Natl. Acad. Sci. U.S.A. 2019;116 (38):19098-19108. doi: 10.1073/pnas.1813495116. PubMed PMID:31471491 PubMed Central PMC6754609.
  12. Sbihi, H, Jones, MJ, MacIsaac, JL, Brauer, M, Allen, RW, Sears, MR et al.. Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization. J. Allergy Clin. Immunol. 2019; :. doi: 10.1016/j.jaci.2019.07.047. PubMed PMID:31470034 .
  13. Gervin, K, Salas, LA, Bakulski, KM, van Zelm, MC, Koestler, DC, Wiencke, JK et al.. Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data. Clin Epigenetics. 2019;11 (1):125. doi: 10.1186/s13148-019-0717-y. PubMed PMID:31455416 PubMed Central PMC6712867.
  14. Badran, M, Yassin, BA, Lin, DTS, Kobor, MS, Ayas, N, Laher, I et al.. Gestational intermittent hypoxia induces endothelial dysfunction, reduces perivascular adiponectin and causes epigenetic changes in adult male offspring. J. Physiol. (Lond.). 2019;597 (22):5349-5364. doi: 10.1113/JP277936. PubMed PMID:31441069 .
  15. Letourneau, NL, de Koning, APJ, Sekhon, B, Ntanda, HN, Kobor, M, Deane, AJ et al.. Parenting Interacts With Plasticity Genes in Predicting Behavioral Outcomes in Preschoolers. Can J Nurs Res. 2019; :844562119863612. doi: 10.1177/0844562119863612. PubMed PMID:31403319 .
  16. Sundermann, EE, Hussain, MA, Moore, DJ, Horvath, S, Lin, DTS, Kobor, MS et al.. Inflammation-related genes are associated with epigenetic aging in HIV. J. Neurovirol. 2019; :. doi: 10.1007/s13365-019-00777-4. PubMed PMID:31286441 .
  17. Czamara, D, Eraslan, G, Page, CM, Lahti, J, Lahti-Pulkkinen, M, Hämäläinen, E et al.. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nat Commun. 2019;10 (1):2548. doi: 10.1038/s41467-019-10461-0. PubMed PMID:31186427 PubMed Central PMC6559955.
  18. Ong, ML, Tuan, TA, Poh, J, Teh, AL, Chen, L, Pan, H et al.. Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome. Genes Brain Behav. 2019;18 (7):e12576. doi: 10.1111/gbb.12576. PubMed PMID:31020763 .
  19. van Kuilenburg, ABP, Tarailo-Graovac, M, Richmond, PA, Drögemöller, BI, Pouladi, MA, Leen, R et al.. Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS. N. Engl. J. Med. 2019;380 (15):1433-1441. doi: 10.1056/NEJMoa1806627. PubMed PMID:30970188 .
  20. Hari Dass, SA, McCracken, K, Pokhvisneva, I, Chen, LM, Garg, E, Nguyen, TTT et al.. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine. 2019;42 :188-202. doi: 10.1016/j.ebiom.2019.03.051. PubMed PMID:30922963 PubMed Central PMC6491717.
  21. Toepfer, P, O'Donnell, KJ, Entringer, S, Heim, CM, Lin, DTS, MacIsaac, JL et al.. A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment. J Am Acad Child Adolesc Psychiatry. 2019;58 (12):1207-1216. doi: 10.1016/j.jaac.2019.03.006. PubMed PMID:30858011 PubMed Central PMC6733663.
  22. McDade, TW, Ryan, CP, Jones, MJ, Hoke, MK, Borja, J, Miller, GE et al.. Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood. Am. J. Phys. Anthropol. 2019;169 (1):3-11. doi: 10.1002/ajpa.23800. PubMed PMID:30771258 .
  23. Wu, Y, Lin, X, Lim, IY, Chen, L, Teh, AL, MacIsaac, JL et al.. Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm. Clin Epigenetics. 2019;11 (1):26. doi: 10.1186/s13148-018-0599-4. PubMed PMID:30744680 PubMed Central PMC6371604.
  24. Toepfer, P, O'Donnell, KJ, Entringer, S, Garg, E, Heim, CM, Lin, DTS et al.. Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness. Psychoneuroendocrinology. 2019;103 :156-162. doi: 10.1016/j.psyneuen.2019.01.013. PubMed PMID:30690225 PubMed Central PMC6554513.
  25. Brown, JAR, Kobor, MS. Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage. DNA Repair (Amst.). 2019;74 :1-16. doi: 10.1016/j.dnarep.2019.01.001. PubMed PMID:30639951 .
  26. Islam, SA, Goodman, SJ, MacIsaac, JL, Obradović, J, Barr, RG, Boyce, WT et al.. Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation. Epigenetics Chromatin. 2019;12 (1):1. doi: 10.1186/s13072-018-0245-6. PubMed PMID:30602389 PubMed Central PMC6314079.
  27. Lussier, AA, Bodnar, TS, Mingay, M, Morin, AM, Hirst, M, Kobor, MS et al.. Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues. Front Genet. 2018;9 :610. doi: 10.3389/fgene.2018.00610. PubMed PMID:30568673 PubMed Central PMC6290329.
  28. Husquin, LT, Rotival, M, Fagny, M, Quach, H, Zidane, N, McEwen, LM et al.. Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation. Genome Biol. 2018;19 (1):222. doi: 10.1186/s13059-018-1601-3. PubMed PMID:30563547 PubMed Central PMC6299574.
  29. Barha, CK, Salvante, KG, Jones, MJ, Farré, P, Blais, J, Kobor, MS et al.. Early post-conception maternal cortisol, children's HPAA activity and DNA methylation profiles. J Dev Orig Health Dis. 2019;10 (1):73-87. doi: 10.1017/S2040174418000880. PubMed PMID:30428949 .
  30. Bush, NR, Edgar, RD, Park, M, MacIsaac, JL, McEwen, LM, Adler, NE et al.. The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation. Epigenomics. 2018;10 (11):1445-1461. doi: 10.2217/epi-2018-0042. PubMed PMID:30351206 PubMed Central PMC6462839.
  31. McEwen, LM, Jones, MJ, Lin, DTS, Edgar, RD, Husquin, LT, MacIsaac, JL et al.. Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array. Clin Epigenetics. 2018;10 (1):123. doi: 10.1186/s13148-018-0556-2. PubMed PMID:30326963 PubMed Central PMC6192219.
  32. Roberts, AL, Gladish, N, Gatev, E, Jones, MJ, Chen, Y, MacIsaac, JL et al.. Exposure to childhood abuse is associated with human sperm DNA methylation. Transl Psychiatry. 2018;8 (1):194. doi: 10.1038/s41398-018-0252-1. PubMed PMID:30279435 PubMed Central PMC6168447.
  33. Lin, X, Tan, JYL, Teh, AL, Lim, IY, Liew, SJ, MacIsaac, JL et al.. Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types. Epigenetics. 2018;13 (9):941-958. doi: 10.1080/15592294.2018.1522929. PubMed PMID:30232931 PubMed Central PMC6284779.
  34. Goodman, SJ, Roubinov, DS, Bush, NR, Park, M, Farré, P, Emberly, E et al.. Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood. Dev Sci. 2019;22 (2):e12739. doi: 10.1111/desc.12739. PubMed PMID:30176105 PubMed Central PMC6433477.
  35. Chen, LM, Yao, N, Garg, E, Zhu, Y, Nguyen, TTT, Pokhvisneva, I et al.. PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores. BMC Bioinformatics. 2018;19 (1):295. doi: 10.1186/s12859-018-2289-9. PubMed PMID:30089455 PubMed Central PMC6083617.
  36. Moore, SR, Kobor, MS. Variability in DNA methylation at the serotonin transporter gene promoter: epigenetic mechanism or cell-type artifact?. Mol. Psychiatry. 2018; :. doi: 10.1038/s41380-018-0121-6. PubMed PMID:30082839 .
  37. Conradt, E, Adkins, DE, Crowell, SE, Monk, C, Kobor, MS. An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior. Dev. Psychopathol. 2018;30 (3):881-890. doi: 10.1017/S0954579418000688. PubMed PMID:30068429 PubMed Central PMC6074043.
  38. Garg, E, Chen, L, Nguyen, TTT, Pokhvisneva, I, Chen, LM, Unternaehrer, E et al.. The early care environment and DNA methylome variation in childhood. Dev. Psychopathol. 2018;30 (3):891-903. doi: 10.1017/S0954579418000627. PubMed PMID:30068421 .
  39. Solomon, O, MacIsaac, J, Quach, H, Tindula, G, Kobor, MS, Huen, K et al.. Comparison of DNA methylation measured by Illumina 450K and EPIC BeadChips in blood of newborns and 14-year-old children. Epigenetics. 2018;13 (6):655-664. doi: 10.1080/15592294.2018.1497386. PubMed PMID:30044683 PubMed Central PMC6140901.
  40. Ryan, CP, Hayes, MG, Lee, NR, McDade, TW, Jones, MJ, Kobor, MS et al.. Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women. Sci Rep. 2018;8 (1):11100. doi: 10.1038/s41598-018-29486-4. PubMed PMID:30038336 PubMed Central PMC6056536.
  41. Austin, MK, Chen, E, Ross, KM, McEwen, LM, Maclsaac, JL, Kobor, MS et al.. Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes. Psychoneuroendocrinology. 2018;97 :131-134. doi: 10.1016/j.psyneuen.2018.07.007. PubMed PMID:30016711 .
  42. Horvath, S, Stein, DJ, Phillips, N, Heany, SJ, Kobor, MS, Lin, DTS et al.. Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents. AIDS. 2018;32 (11):1465-1474. doi: 10.1097/QAD.0000000000001854. PubMed PMID:29746298 PubMed Central PMC6026068.
  43. Clifford, RL, Fishbane, N, Patel, J, MacIsaac, JL, McEwen, LM, Fisher, AJ et al.. Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD. Clin Epigenetics. 2018;10 :32. doi: 10.1186/s13148-018-0464-5. PubMed PMID:29527240 PubMed Central PMC5838860.
  44. Islam, SA, Lussier, AA, Kobor, MS. Epigenetic analysis of human postmortem brain tissue. Handb Clin Neurol. 2018;150 :237-261. doi: 10.1016/B978-0-444-63639-3.00017-7. PubMed PMID:29496144 .
  45. Forest, M, O'Donnell, KJ, Voisin, G, Gaudreau, H, MacIsaac, JL, McEwen, LM et al.. Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time. Epigenetics. 2018;13 (1):19-32. doi: 10.1080/15592294.2017.1411443. PubMed PMID:29381404 PubMed Central PMC5837078.
  46. Gonzalez, A, Catherine, N, Boyle, M, Jack, SM, Atkinson, L, Kobor, M et al.. Healthy Foundations Study: a randomised controlled trial to evaluate biological embedding of early-life experiences. BMJ Open. 2018;8 (1):e018915. doi: 10.1136/bmjopen-2017-018915. PubMed PMID:29374668 PubMed Central PMC5829768.
  47. Lussier, AA, Morin, AM, MacIsaac, JL, Salmon, J, Weinberg, J, Reynolds, JN et al.. DNA methylation as a predictor of fetal alcohol spectrum disorder. Clin Epigenetics. 2018;10 :5. doi: 10.1186/s13148-018-0439-6. PubMed PMID:29344313 PubMed Central PMC5767049.
  48. O'Donnell, KJ, Chen, L, MacIsaac, JL, McEwen, LM, Nguyen, T, Beckmann, K et al.. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Transl Psychiatry. 2018;8 (1):15. doi: 10.1038/s41398-017-0063-9. PubMed PMID:29317599 PubMed Central PMC5802588.
  49. Lin, X, Teh, AL, Chen, L, Lim, IY, Tan, PF, MacIsaac, JL et al.. Choice of surrogate tissue influences neonatal EWAS findings. BMC Med. 2017;15 (1):211. doi: 10.1186/s12916-017-0970-x. PubMed PMID:29202839 PubMed Central PMC5715509.
  50. Carja, O, MacIsaac, JL, Mah, SM, Henn, BM, Kobor, MS, Feldman, MW et al.. Worldwide patterns of human epigenetic variation. Nat Ecol Evol. 2017;1 (10):1577-1583. doi: 10.1038/s41559-017-0299-z. PubMed PMID:29185505 .
  51. Moore, SR, McEwen, LM, Quirt, J, Morin, A, Mah, SM, Barr, RG et al.. Epigenetic correlates of neonatal contact in humans. Dev. Psychopathol. 2017;29 (5):1517-1538. doi: 10.1017/S0954579417001213. PubMed PMID:29162165 .
  52. McEwen, LM, Gatev, EG, Jones, MJ, MacIsaac, JL, McAllister, MM, Goulding, RE et al.. DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial. Appl Physiol Nutr Metab. 2018;43 (3):233-239. doi: 10.1139/apnm-2017-0436. PubMed PMID:29049890 .
  53. Chang, EY, Novoa, CA, Aristizabal, MJ, Coulombe, Y, Segovia, R, Chaturvedi, R et al.. RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability. J. Cell Biol. 2017;216 (12):3991-4005. doi: 10.1083/jcb.201703168. PubMed PMID:29042409 PubMed Central PMC5716281.
  54. Jones, MJ, Moore, SR, Kobor, MS. Principles and Challenges of Applying Epigenetic Epidemiology to Psychology. Annu Rev Psychol. 2018;69 :459-485. doi: 10.1146/annurev-psych-122414-033653. PubMed PMID:29035689 .
  55. Verschoor, CP, McEwen, LM, Kobor, MS, Loeb, MB, Bowdish, DME. DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly. Exp. Gerontol. 2018;105 :47-52. doi: 10.1016/j.exger.2017.10.010. PubMed PMID:29032243 .
  56. McDade, TW, Jones, MJ, Miller, G, Borja, J, Kobor, MS, Kuzawa, CW et al.. Birth weight and postnatal microbial exposures predict the distribution of peripheral blood leukocyte subsets in young adults in the Philippines. J Dev Orig Health Dis. 2018;9 (2):198-207. doi: 10.1017/S2040174417000794. PubMed PMID:29017617 .
  57. Mang, CS, McEwen, LM, MacIsaac, JL, Snow, NJ, Campbell, KL, Kobor, MS et al.. Exploring genetic influences underlying acute aerobic exercise effects on motor learning. Sci Rep. 2017;7 (1):12123. doi: 10.1038/s41598-017-12422-3. PubMed PMID:28935933 PubMed Central PMC5608967.
  58. Davis, EG, Humphreys, KL, McEwen, LM, Sacchet, MD, Camacho, MC, MacIsaac, JL et al.. Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume. Transl Psychiatry. 2017;7 (8):e1223. doi: 10.1038/tp.2017.188. PubMed PMID:28850111 PubMed Central PMC5611751.
  59. Morin, AM, Gatev, E, McEwen, LM, MacIsaac, JL, Lin, DTS, Koen, N et al.. Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs. Clin Epigenetics. 2017;9 :75. doi: 10.1186/s13148-017-0370-2. PubMed PMID:28770015 PubMed Central PMC5526324.
  60. Edgar, RD, Jones, MJ, Meaney, MJ, Turecki, G, Kobor, MS. BECon: a tool for interpreting DNA methylation findings from blood in the context of brain. Transl Psychiatry. 2017;7 (8):e1187. doi: 10.1038/tp.2017.171. PubMed PMID:28763057 PubMed Central PMC5611738.
  61. North, ML, Jones, MJ, MacIsaac, JL, Morin, AM, Steacy, LM, Gregor, A et al.. Blood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit. Allergy. 2018;73 (1):196-205. doi: 10.1111/all.13263. PubMed PMID:28755526 .
  62. Brückmann, C, Islam, SA, MacIsaac, JL, Morin, AM, Karle, KN, Di Santo, A et al.. DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment. Sci Rep. 2017;7 (1):6605. doi: 10.1038/s41598-017-06847-z. PubMed PMID:28747766 PubMed Central PMC5529570.
  63. McDade, TW, Ryan, C, Jones, MJ, MacIsaac, JL, Morin, AM, Meyer, JM et al.. Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (29):7611-7616. doi: 10.1073/pnas.1620661114. PubMed PMID:28673994 PubMed Central PMC5530653.
  64. Verschoor, CP, McEwen, LM, Kohli, V, Wolfson, C, Bowdish, DM, Raina, P et al.. The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study. BMC Genet. 2017;18 (1):57. doi: 10.1186/s12863-017-0525-3. PubMed PMID:28637423 PubMed Central PMC5480116.
  65. Gopalan, S, Carja, O, Fagny, M, Patin, E, Myrick, JW, McEwen, LM et al.. Trends in DNA Methylation with Age Replicate Across Diverse Human Populations. Genetics. 2017;206 (3):1659-1674. doi: 10.1534/genetics.116.195594. PubMed PMID:28533441 PubMed Central PMC5500158.
  66. Girchenko, P, Lahti, J, Czamara, D, Knight, AK, Jones, MJ, Suarez, A et al.. Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth. Clin Epigenetics. 2017;9 :49. doi: 10.1186/s13148-017-0349-z. PubMed PMID:28503212 PubMed Central PMC5422977.
  67. Budinger, GRS, Kohanski, RA, Gan, W, Kobor, MS, Amaral, LA, Armanios, M et al.. The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J. Gerontol. A Biol. Sci. Med. Sci. 2017;72 (11):1492-1500. doi: 10.1093/gerona/glx090. PubMed PMID:28498894 PubMed Central PMC5861849.
  68. McEwen, LM, Morin, AM, Edgar, RD, MacIsaac, JL, Jones, MJ, Dow, WH et al.. Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region. Epigenetics Chromatin. 2017;10 :21. doi: 10.1186/s13072-017-0128-2. PubMed PMID:28465725 PubMed Central PMC5408416.
  69. Lin, X, Lim, IY, Wu, Y, Teh, AL, Chen, L, Aris, IM et al.. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Med. 2017;15 (1):50. doi: 10.1186/s12916-017-0800-1. PubMed PMID:28264723 PubMed Central PMC5340003.
  70. Leung, JM, Fishbane, N, Jones, M, Morin, A, Xu, S, Liu, JC et al.. Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion. Aging (Albany NY). 2017;9 (3):687-705. doi: 10.18632/aging.101184. PubMed PMID:28237978 PubMed Central PMC5391226.
  71. Lussier, AA, Weinberg, J, Kobor, MS. Epigenetics studies of fetal alcohol spectrum disorder: where are we now?. Epigenomics. 2017;9 (3):291-311. doi: 10.2217/epi-2016-0163. PubMed PMID:28234026 PubMed Central PMC5549650.
  72. Edgar, RD, Jones, MJ, Robinson, WP, Kobor, MS. An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs. Clin Epigenetics. 2017;9 :11. doi: 10.1186/s13148-017-0320-z. PubMed PMID:28184257 PubMed Central PMC5290610.
  73. Gref, A, Merid, SK, Gruzieva, O, Ballereau, S, Becker, A, Bellander, T et al.. Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up. Am. J. Respir. Crit. Care Med. 2017;195 (10):1373-1383. doi: 10.1164/rccm.201605-1026OC. PubMed PMID:27901618 PubMed Central PMC5443897.
  74. Steunou, AL, Cramet, M, Rossetto, D, Aristizabal, MJ, Lacoste, N, Drouin, S et al.. Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome. Mol. Cell. Biol. 2016;36 (22):2768-2781. doi: 10.1128/MCB.00112-16. PubMed PMID:27550811 PubMed Central PMC5086519.
  75. Esposito, EA, Jones, MJ, Doom, JR, MacIsaac, JL, Gunnar, MR, Kobor, MS et al.. Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity. Dev. Psychopathol. 2016;28 (4pt2):1385-1399. doi: 10.1017/S0954579416000055. PubMed PMID:26847422 PubMed Central PMC5903568.
  76. Horvath, S, Gurven, M, Levine, ME, Trumble, BC, Kaplan, H, Allayee, H et al.. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biol. 2016;17 (1):171. doi: 10.1186/s13059-016-1030-0. PubMed PMID:27511193 PubMed Central PMC4980791.
  77. Portales-Casamar, E, Lussier, AA, Jones, MJ, MacIsaac, JL, Edgar, RD, Mah, SM et al.. DNA methylation signature of human fetal alcohol spectrum disorder. Epigenetics Chromatin. 2016;9 :25. doi: 10.1186/s13072-016-0074-4. PubMed PMID:27358653 PubMed Central PMC4926300.
  78. Clifford, RL, Jones, MJ, MacIsaac, JL, McEwen, LM, Goodman, SJ, Mostafavi, S et al.. Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation. J. Allergy Clin. Immunol. 2017;139 (1):112-121. doi: 10.1016/j.jaci.2016.03.046. PubMed PMID:27321436 .
  79. Robert McMaster, W, Morrison, CJ, Kobor, MS. Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation. Trends Parasitol. 2016;32 (7):515-521. doi: 10.1016/j.pt.2016.04.002. PubMed PMID:27142564 .
  80. Aristizabal, MJ, Kobor, MS. A single flexible RNAPII-CTD integrates many different transcriptional programs. Transcription. 2016;7 (2):50-6. doi: 10.1080/21541264.2016.1163451. PubMed PMID:26985717 PubMed Central PMC4853039.
  81. Koestler, DC, Jones, MJ, Usset, J, Christensen, BC, Butler, RA, Kobor, MS et al.. Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL). BMC Bioinformatics. 2016;17 :120. doi: 10.1186/s12859-016-0943-7. PubMed PMID:26956433 PubMed Central PMC4782368.
  82. De Souza, RA, Islam, SA, McEwen, LM, Mathelier, A, Hill, A, Mah, SM et al.. DNA methylation profiling in human Huntington's disease brain. Hum. Mol. Genet. 2016;25 (10):2013-2030. doi: 10.1093/hmg/ddw076. PubMed PMID:26953320 .
  83. Buschdorf, JP, Ong, ML, Ong, SX, MacIsaac, JL, Chng, K, Kobor, MS et al.. Low birth weight associates with hippocampal gene expression. Neuroscience. 2016;318 :190-205. doi: 10.1016/j.neuroscience.2016.01.013. PubMed PMID:26791528 .
  84. Teh, AL, Pan, H, Lin, X, Lim, YI, Patro, CP, Cheong, CY et al.. Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples. Epigenetics. 2016;11 (1):36-48. doi: 10.1080/15592294.2015.1132136. PubMed PMID:26786415 PubMed Central PMC4846133.
  85. Leung, GP, Brown, JA, Glover, JN, Kobor, MS. Rtt107 BRCT domains act as a targeting module in the DNA damage response. DNA Repair (Amst.). 2016;37 :22-32. doi: 10.1016/j.dnarep.2015.10.007. PubMed PMID:26641499 .
  86. Fagny, M, Patin, E, MacIsaac, JL, Rotival, M, Flutre, T, Jones, MJ et al.. The epigenomic landscape of African rainforest hunter-gatherers and farmers. Nat Commun. 2015;6 :10047. doi: 10.1038/ncomms10047. PubMed PMID:26616214 PubMed Central PMC4674682.
  87. Oros Klein, K, Grinek, S, Bernatsky, S, Bouchard, L, Ciampi, A, Colmegna, I et al.. funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types. Bioinformatics. 2016;32 (4):593-5. doi: 10.1093/bioinformatics/btv615. PubMed PMID:26500152 PubMed Central PMC4743629.
  88. Aristizabal, MJ, Negri, GL, Kobor, MS. The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition. PLoS Genet. 2015;11 (10):e1005608. doi: 10.1371/journal.pgen.1005608. PubMed PMID:26496706 PubMed Central PMC4619828.
  89. Pacis, A, Tailleux, L, Morin, AM, Lambourne, J, MacIsaac, JL, Yotova, V et al.. Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. 2015;25 (12):1801-11. doi: 10.1101/gr.192005.115. PubMed PMID:26392366 PubMed Central PMC4665002.
  90. de Goede, OM, Razzaghian, HR, Price, EM, Jones, MJ, Kobor, MS, Robinson, WP et al.. Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells. Clin Epigenetics. 2015;7 :95. doi: 10.1186/s13148-015-0129-6. PubMed PMID:26366232 PubMed Central PMC4567832.
  91. Lussier, AA, Stepien, KA, Weinberg, J, Kobor, MS. Prenatal alcohol exposure alters gene expression in the rat brain: Experimental design and bioinformatic analysis of microarray data. Data Brief. 2015;4 :239-52. doi: 10.1016/j.dib.2015.05.007. PubMed PMID:26217797 PubMed Central PMC4510447.
  92. Jones, MJ, Islam, SA, Edgar, RD, Kobor, MS. Adjusting for Cell Type Composition in DNA Methylation Data Using a Regression-Based Approach. Methods Mol. Biol. 2017;1589 :99-106. doi: 10.1007/7651_2015_262. PubMed PMID:26126446 .
  93. Beery, AK, McEwen, LM, MacIsaac, JL, Francis, DD, Kobor, MS. Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Horm Behav. 2016;77 :42-52. doi: 10.1016/j.yhbeh.2015.05.022. PubMed PMID:26122287 PubMed Central PMC4691570.
  94. Subbarao, P, Anand, SS, Becker, AB, Befus, AD, Brauer, M, Brook, JR et al.. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax. 2015;70 (10):998-1000. doi: 10.1136/thoraxjnl-2015-207246. PubMed PMID:26069286 .
  95. Pan, H, Lin, X, Wu, Y, Chen, L, Teh, AL, Soh, SE et al.. HIF3A association with adiposity: the story begins before birth. Epigenomics. 2015;7 (6):937-50. doi: 10.2217/epi.15.45. PubMed PMID:26011824 PubMed Central PMC4863876.
  96. Farré, P, Jones, MJ, Meaney, MJ, Emberly, E, Turecki, G, Kobor, MS et al.. Concordant and discordant DNA methylation signatures of aging in human blood and brain. Epigenetics Chromatin. 2015;8 :19. doi: 10.1186/s13072-015-0011-y. PubMed PMID:25977707 PubMed Central PMC4430927.
  97. Jones, MJ, Goodman, SJ, Kobor, MS. DNA methylation and healthy human aging. Aging Cell. 2015;14 (6):924-32. doi: 10.1111/acel.12349. PubMed PMID:25913071 PubMed Central PMC4693469.
  98. Kaplow, IM, MacIsaac, JL, Mah, SM, McEwen, LM, Kobor, MS, Fraser, HB et al.. A pooling-based approach to mapping genetic variants associated with DNA methylation. Genome Res. 2015;25 (6):907-17. doi: 10.1101/gr.183749.114. PubMed PMID:25910490 PubMed Central PMC4448686.
  99. Gurnot, C, Martin-Subero, I, Mah, SM, Weikum, W, Goodman, SJ, Brain, U et al.. Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates. Epigenetics. 2015;10 (5):361-72. doi: 10.1080/15592294.2015.1026031. PubMed PMID:25891251 PubMed Central PMC4622680.
  100. Lussier, AA, Stepien, KA, Neumann, SM, Pavlidis, P, Kobor, MS, Weinberg, J et al.. Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain. Alcohol. Clin. Exp. Res. 2015;39 (2):251-61. doi: 10.1111/acer.12622. PubMed PMID:25684047 PubMed Central PMC4833439.
Search PubMed