Daniel Goldowitz Publications

  1. Ha, TJ, Zhang, PGY, Robert, R, Yeung, J, Swanson, DJ, Mathelier, A et al.. Identification of novel cerebellar developmental transcriptional regulators with motif activity analysis. BMC Genomics. 2019;20 (1):718. doi: 10.1186/s12864-019-6063-9. PubMed PMID:31533632 PubMed Central PMC6751898.
  2. Korecki, AJ, Hickmott, JW, Lam, SL, Dreolini, L, Mathelier, A, Baker, O et al.. Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele. Genetics. 2019;211 (4):1155-1177. doi: 10.1534/genetics.119.301984. PubMed PMID:30765420 PubMed Central PMC6456315.
  3. Ranger, M, Tremblay, S, Chau, CMY, Holsti, L, Grunau, RE, Goldowitz, D et al.. Adverse Behavioral Changes in Adult Mice Following Neonatal Repeated Exposure to Pain and Sucrose. Front Psychol. 2018;9 :2394. doi: 10.3389/fpsyg.2018.02394. PubMed PMID:30719013 PubMed Central PMC6348336.
  4. Théberge, ET, Baker, JA, Dubose, C, Boyle, JK, Balce, K, Goldowitz, D et al.. Genetic Influences on the Amount of Cell Death in the Neural Tube of BXD Mice Exposed to Acute Ethanol at Midgestation. Alcohol. Clin. Exp. Res. 2019;43 (3):439-452. doi: 10.1111/acer.13947. PubMed PMID:30589433 PubMed Central PMC6410727.
  5. Zhang, P, Dimont, E, Ha, T, Swanson, DJ, Itoh, M, Kawaji, H et al.. Correction to: Relatively frequent switching of transcription start sites during cerebellar development. BMC Genomics. 2018;19 (1):39. doi: 10.1186/s12864-017-4291-4. PubMed PMID:29325522 PubMed Central PMC5763542.
  6. Zhang, PGY, Yeung, J, Gupta, I, Ramirez, M, Ha, T, Swanson, DJ et al.. Discovery of Transcription Factors Novel to Mouse Cerebellar Granule Cell Development Through Laser-Capture Microdissection. Cerebellum. 2018;17 (3):308-325. doi: 10.1007/s12311-017-0912-3. PubMed PMID:29307116 .
  7. Connell, M, Chen, H, Jiang, J, Kuan, CW, Fotovati, A, Chu, TL et al.. HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. Elife. 2017;6 :. doi: 10.7554/eLife.28672. PubMed PMID:28994651 PubMed Central PMC5681225.
  8. Roy, S, Yun, D, Madahian, B, Berry, MW, Deng, LY, Goldowitz, D et al.. Navigating the Functional Landscape of Transcription Factors via Non-Negative Tensor Factorization Analysis of MEDLINE Abstracts. Front Bioeng Biotechnol. 2017;5 :48. doi: 10.3389/fbioe.2017.00048. PubMed PMID:28894735 PubMed Central PMC5581332.
  9. Noguchi, S, Arakawa, T, Fukuda, S, Furuno, M, Hasegawa, A, Hori, F et al.. FANTOM5 CAGE profiles of human and mouse samples. Sci Data. 2017;4 :170112. doi: 10.1038/sdata.2017.112. PubMed PMID:28850106 PubMed Central PMC5574368.
  10. de Rie, D, Abugessaisa, I, Alam, T, Arner, E, Arner, P, Ashoor, H et al.. An integrated expression atlas of miRNAs and their promoters in human and mouse. Nat. Biotechnol. 2017;35 (9):872-878. doi: 10.1038/nbt.3947. PubMed PMID:28829439 PubMed Central PMC5767576.
  11. Tremblay, S, Pai, A, Richter, L, Vafaei, R, Potluri, P, Ellegood, J et al.. Systemic inflammation combined with neonatal cerebellar haemorrhage aggravates long-term structural and functional outcomes in a mouse model. Brain Behav. Immun. 2017;66 :257-276. doi: 10.1016/j.bbi.2017.07.013. PubMed PMID:28755859 .
  12. Tremblay, S, Ranger, M, Chau, CMY, Ellegood, J, Lerch, JP, Holsti, L et al.. Repeated exposure to sucrose for procedural pain in mouse pups leads to long-term widespread brain alterations. Pain. 2017;158 (8):1586-1598. doi: 10.1097/j.pain.0000000000000961. PubMed PMID:28715355 PubMed Central PMC5539923.
  13. Zhang, P, Dimont, E, Ha, T, Swanson, DJ, FANTOM Consortium, Hide, W et al.. Relatively frequent switching of transcription start sites during cerebellar development. BMC Genomics. 2017;18 (1):461. doi: 10.1186/s12864-017-3834-z. PubMed PMID:28610618 PubMed Central PMC5470264.
  14. Yeung, J, Goldowitz, D. Wls expression in the rhombic lip orchestrates the embryonic development of the mouse cerebellum. Neuroscience. 2017;354 :30-42. doi: 10.1016/j.neuroscience.2017.04.020. PubMed PMID:28450263 .
  15. Yeung, J, Ha, TJ, Swanson, DJ, Goldowitz, D. A Novel and Multivalent Role of Pax6 in Cerebellar Development. J. Neurosci. 2016;36 (35):9057-69. doi: 10.1523/JNEUROSCI.4385-15.2016. PubMed PMID:27581449 PubMed Central PMC5005719.
  16. Calton, MA, Howard, JR, Harper, RM, Goldowitz, D, Mittleman, G. The Cerebellum and SIDS: Disordered Breathing in a Mouse Model of Developmental Cerebellar Purkinje Cell Loss during Recovery from Hypercarbia. Front Neurol. 2016;7 :78. doi: 10.3389/fneur.2016.00078. PubMed PMID:27242661 PubMed Central PMC4865515.
  17. de Leeuw, CN, Korecki, AJ, Berry, GE, Hickmott, JW, Lam, SL, Lengyell, TC et al.. rAAV-compatible MiniPromoters for restricted expression in the brain and eye. Mol Brain. 2016;9 (1):52. doi: 10.1186/s13041-016-0232-4. PubMed PMID:27164903 PubMed Central PMC4862195.
  18. Dickson, PE, Cairns, J, Goldowitz, D, Mittleman, G. Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice. Neuroscience. 2017;345 :99-109. doi: 10.1016/j.neuroscience.2016.03.040. PubMed PMID:27012612 PubMed Central PMC5031514.
  19. Cairns, J, Swanson, D, Yeung, J, Sinova, A, Chan, R, Potluri, P et al.. Abnormalities in the Structure and Function of Cerebellar Neurons and Neuroglia in the Lc/+ Chimeric Mouse Model of Variable Developmental Purkinje Cell Loss. Cerebellum. 2017;16 (1):40-54. doi: 10.1007/s12311-015-0756-7. PubMed PMID:26837618 .
  20. Dickson, PE, Miller, MM, Calton, MA, Bubier, JA, Cook, MN, Goldowitz, D et al.. Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel. Psychopharmacology (Berl.). 2016;233 (4):701-14. doi: 10.1007/s00213-015-4147-z. PubMed PMID:26581503 PubMed Central PMC4803082.
  21. Zhang, P, Ha, T, Larouche, M, Swanson, D, Goldowitz, D. Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. PLoS ONE. 2015;10 (7):e0134390. doi: 10.1371/journal.pone.0134390. PubMed PMID:26226504 PubMed Central PMC4520560.
  22. Arner, E, Daub, CO, Vitting-Seerup, K, Andersson, R, Lilje, B, Drabløs, F et al.. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 2015;347 (6225):1010-4. doi: 10.1126/science.1259418. PubMed PMID:25678556 PubMed Central PMC4681433.
  23. Vitezic, M, Bertin, N, Andersson, R, Lipovich, L, Kawaji, H, Lassmann, T et al.. CAGE-defined promoter regions of the genes implicated in Rett Syndrome. BMC Genomics. 2014;15 :1177. doi: 10.1186/1471-2164-15-1177. PubMed PMID:25539566 PubMed Central PMC4522966.
  24. Ha, T, Swanson, D, Larouche, M, Glenn, R, Weeden, D, Zhang, P et al.. CbGRiTS: cerebellar gene regulation in time and space. Dev. Biol. 2015;397 (1):18-30. doi: 10.1016/j.ydbio.2014.09.032. PubMed PMID:25446528 .
  25. Yeung, J, Ha, TJ, Swanson, DJ, Choi, K, Tong, Y, Goldowitz, D et al.. Wls provides a new compartmental view of the rhombic lip in mouse cerebellar development. J. Neurosci. 2014;34 (37):12527-37. doi: 10.1523/JNEUROSCI.1330-14.2014. PubMed PMID:25209290 PubMed Central PMC4160781.
  26. Calton, M, Dickson, P, Harper, RM, Goldowitz, D, Mittleman, G. Impaired hypercarbic and hypoxic responses from developmental loss of cerebellar Purkinje neurons: implications for sudden infant death syndrome. Cerebellum. 2014;13 (6):739-50. doi: 10.1007/s12311-014-0592-1. PubMed PMID:25132500 PubMed Central PMC4462133.
  27. Goldowitz, D, Lussier, AA, Boyle, JK, Wong, K, Lattimer, SL, Dubose, C et al.. Molecular pathways underpinning ethanol-induced neurodegeneration. Front Genet. 2014;5 :203. doi: 10.3389/fgene.2014.00203. PubMed PMID:25076964 PubMed Central PMC4097813.
  28. de Leeuw, CN, Dyka, FM, Boye, SL, Laprise, S, Zhou, M, Chou, AY et al.. Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors. Mol Ther Methods Clin Dev. 2014;1 :5. doi: 10.1038/mtm.2013.5. PubMed PMID:24761428 PubMed Central PMC3992516.
  29. FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest, AR, Kawaji, H, Rehli, M, Baillie, JK, de Hoon, MJ et al.. A promoter-level mammalian expression atlas. Nature. 2014;507 (7493):462-70. doi: 10.1038/nature13182. PubMed PMID:24670764 PubMed Central PMC4529748.
  30. Poon, A, Goldowitz, D. Identification of genetic loci that modulate cell proliferation in the adult rostral migratory stream using the expanded panel of BXD mice. BMC Genomics. 2014;15 :206. doi: 10.1186/1471-2164-15-206. PubMed PMID:24640950 PubMed Central PMC4004255.
  31. Mary-Sinclair, MN, Wang, X, Swanson, DJ, Sung, CY, Mendonca, EA, Wroblewski, K et al.. Varied manifestations of persistent hyperplastic primary vitreous with graded somatic mosaic deletion of a single gene. Mol. Vis. 2014;20 :215-30. . PubMed PMID:24623965 PubMed Central PMC3945809.
  32. Balsevich, G, Poon, A, Goldowitz, D, Wilking, JA. The effects of pre- and post-natal nicotine exposure and genetic background on the striatum and behavioral phenotypes in the mouse. Behav. Brain Res. 2014;266 :7-18. doi: 10.1016/j.bbr.2014.02.038. PubMed PMID:24607511 .
  33. Racine, E, Bell, E, Yan, A, Andrew, G, Bell, LE, Clarke, M et al.. Ethics challenges of transition from paediatric to adult health care services for young adults with neurodevelopmental disabilities. Paediatr Child Health. 2014;19 (2):65-8. doi: 10.1093/pch/19.2.65. PubMed PMID:24596475 PubMed Central PMC3941669.
  34. McKimm, E, Corkill, B, Goldowitz, D, Albritton, LM, Homayouni, R, Blaha, CD et al.. Glutamate dysfunction associated with developmental cerebellar damage: relevance to autism spectrum disorders. Cerebellum. 2014;13 (3):346-53. doi: 10.1007/s12311-013-0541-4. PubMed PMID:24307139 PubMed Central PMC4060592.
  35. Yoo, JY, Mak, GK, Goldowitz, D. The effect of hemorrhage on the development of the postnatal mouse cerebellum. Exp. Neurol. 2014;252 :85-94. doi: 10.1016/j.expneurol.2013.11.010. PubMed PMID:24252180 .
  36. Schmouth, JF, Castellarin, M, Laprise, S, Banks, KG, Bonaguro, RJ, McInerny, SC et al.. Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice. BMC Biol. 2013;11 :106. doi: 10.1186/1741-7007-11-106. PubMed PMID:24124870 PubMed Central PMC4015596.
  37. Goldowitz, D. Excessive activation of tissue plasminogen activator makes a mouse nervous. Proc. Natl. Acad. Sci. U.S.A. 2013;110 (27):10882-3. doi: 10.1073/pnas.1309965110. PubMed PMID:23792578 PubMed Central PMC3704036.
  38. Dickson, PE, Corkill, B, McKimm, E, Miller, MM, Calton, MA, Goldowitz, D et al.. Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndrome. Behav. Brain Res. 2013;252 :126-35. doi: 10.1016/j.bbr.2013.05.060. PubMed PMID:23747611 PubMed Central PMC3854797.
  39. Rogers, TD, McKimm, E, Dickson, PE, Goldowitz, D, Blaha, CD, Mittleman, G et al.. Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research. Front Syst Neurosci. 2013;7 :15. doi: 10.3389/fnsys.2013.00015. PubMed PMID:23717269 PubMed Central PMC3650713.
  40. Rogers, TD, Dickson, PE, McKimm, E, Heck, DH, Goldowitz, D, Blaha, CD et al.. Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder. Cerebellum. 2013;12 (4):547-56. doi: 10.1007/s12311-013-0462-2. PubMed PMID:23436049 PubMed Central PMC3854915.
  41. Yoo, JY, Larouche, M, Goldowitz, D. The expression of HDAC1 and HDAC2 during cerebellar cortical development. Cerebellum. 2013;12 (4):534-46. doi: 10.1007/s12311-013-0459-x. PubMed PMID:23436026 .
  42. Poon, A, Goldowitz, D. Effects of age and strain on cell proliferation in the mouse rostral migratory stream. Neurobiol. Aging. 2013;34 (6):1712.e15-21. doi: 10.1016/j.neurobiolaging.2012.12.021. PubMed PMID:23369547 .
  43. Qiao, S, Kim, SH, Heck, D, Goldowitz, D, LeDoux, MS, Homayouni, R et al.. Dab2IP GTPase activating protein regulates dendrite development and synapse number in cerebellum. PLoS ONE. 2013;8 (1):e53635. doi: 10.1371/journal.pone.0053635. PubMed PMID:23326475 PubMed Central PMC3541190.
  44. DuBose, CS, Chesler, EJ, Goldowitz, D, Hamre, KM. Use of the expanded panel of BXD mice narrow QTL regions in ethanol-induced locomotor activation and motor incoordination. Alcohol. Clin. Exp. Res. 2013;37 (1):170-83. doi: 10.1111/j.1530-0277.2012.01865.x. PubMed PMID:23289978 .
  45. Liu, L, Hamre, KM, Goldowitz, D. Kainic acid-induced neuronal degeneration in hippocampal pyramidal neurons is driven by both intrinsic and extrinsic factors: analysis of FVB/N↔C57BL/6 chimeras. J. Neurosci. 2012;32 (35):12093-101. doi: 10.1523/JNEUROSCI.6478-11.2012. PubMed PMID:22933793 PubMed Central PMC6621525.
  46. Ha, TJ, Swanson, DJ, Kirova, R, Yeung, J, Choi, K, Tong, Y et al.. Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum. Eur. J. Neurosci. 2012;36 (7):2888-98. doi: 10.1111/j.1460-9568.2012.08221.x. PubMed PMID:22817342 PubMed Central PMC4189819.
  47. Fatemi, SH, Aldinger, KA, Ashwood, P, Bauman, ML, Blaha, CD, Blatt, GJ et al.. Consensus paper: pathological role of the cerebellum in autism. Cerebellum. 2012;11 (3):777-807. doi: 10.1007/s12311-012-0355-9. PubMed PMID:22370873 PubMed Central PMC3677555.
  48. Goldowitz, D. Linking early brain and biological development to psychiatry. J Can Acad Child Adolesc Psychiatry. 2011;20 (4):252. . PubMed PMID:22114606 PubMed Central PMC3222568.
  49. Tong, Y, Ha, TJ, Liu, L, Nishimoto, A, Reiner, A, Goldowitz, D et al.. Spatial and temporal requirements for huntingtin (Htt) in neuronal migration and survival during brain development. J. Neurosci. 2011;31 (41):14794-9. doi: 10.1523/JNEUROSCI.2774-11.2011. PubMed PMID:21994396 PubMed Central PMC3407803.
  50. Ouyang, Z, Song, M, Güth, R, Ha, TJ, Larouche, M, Goldowitz, D et al.. Conserved and differential gene interactions in dynamical biological systems. Bioinformatics. 2011;27 (20):2851-8. doi: 10.1093/bioinformatics/btr472. PubMed PMID:21840874 PubMed Central PMC3187649.
  51. Rogers, TD, Dickson, PE, Heck, DH, Goldowitz, D, Mittleman, G, Blaha, CD et al.. Connecting the dots of the cerebro-cerebellar role in cognitive function: neuronal pathways for cerebellar modulation of dopamine release in the prefrontal cortex. Synapse. 2011;65 (11):1204-12. doi: 10.1002/syn.20960. PubMed PMID:21638338 PubMed Central PMC3854794.
  52. Reynolds, JN, Weinberg, J, Clarren, S, Beaulieu, C, Rasmussen, C, Kobor, M et al.. Fetal alcohol spectrum disorders: gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomes. Semin Pediatr Neurol. 2011;18 (1):49-55. doi: 10.1016/j.spen.2011.02.006. PubMed PMID:21575841 PubMed Central PMC4930322.
  53. Lewis, NJ, Goldowitz, D. NeuroDevNet: A Canada Network of Centres of Excellence--to realize a vision by effective operations and collaborative mechanisms. Semin Pediatr Neurol. 2011;18 (1):5-9. doi: 10.1016/j.spen.2011.02.008. PubMed PMID:21575834 .
  54. Goldowitz, D, McArthur, D. The NeuroDevNet vision. Semin Pediatr Neurol. 2011;18 (1):2-4. doi: 10.1016/j.spen.2011.02.007. PubMed PMID:21575833 .
  55. Shevell, M, Goldowitz, D. Inter-disciplinary research in the pediatric neurosciences: the NeuroDevNet model. Introduction. Semin Pediatr Neurol. 2011;18 (1):1. doi: 10.1016/j.spen.2011.03.001. PubMed PMID:21575832 .
  56. Mittleman, G, Call, SB, Cockroft, JL, Goldowitz, D, Matthews, DB, Blaha, CD et al.. Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: analyses in dopamine transporter knockout mice. Alcohol. 2011;45 (4):325-39. doi: 10.1016/j.alcohol.2010.12.006. PubMed PMID:21354763 PubMed Central PMC3095708.
  57. Di Curzio, DL, Goldowitz, D. The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice. Mamm. Genome. 2011;22 (3-4):209-34. doi: 10.1007/s00335-011-9315-9. PubMed PMID:21347846 .
  58. Dickson, PE, Rogers, TD, Lester, DB, Miller, MM, Matta, SG, Chesler, EJ et al.. Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine. Psychopharmacology (Berl.). 2011;215 (4):631-42. doi: 10.1007/s00213-010-2159-2. PubMed PMID:21212937 .
  59. Lehman, AM, du Souich, C, Chai, D, Eydoux, P, Huang, JL, Fok, AK et al.. 19p13.2 microduplication causes a Sotos syndrome-like phenotype and alters gene expression. Clin. Genet. 2012;81 (1):56-63. doi: 10.1111/j.1399-0004.2010.01615.x. PubMed PMID:21204797 .
  60. Swanson, DJ, Goldowitz, D. Experimental Sey mouse chimeras reveal the developmental deficiencies of Pax6-null granule cells in the postnatal cerebellum. Dev. Biol. 2011;351 (1):1-12. doi: 10.1016/j.ydbio.2010.11.018. PubMed PMID:21126516 .
  61. Portales-Casamar, E, Swanson, DJ, Liu, L, de Leeuw, CN, Banks, KG, Ho Sui, SJ et al.. A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc. Natl. Acad. Sci. U.S.A. 2010;107 (38):16589-94. doi: 10.1073/pnas.1009158107. PubMed PMID:20807748 PubMed Central PMC2944712.
  62. Swanson, DJ, Steshina, EY, Wakenight, P, Aldinger, KA, Goldowitz, D, Millen, KJ et al.. Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele. Eur. J. Neurosci. 2010;32 (5):707-16. doi: 10.1111/j.1460-9568.2010.07330.x. PubMed PMID:20722722 PubMed Central PMC2974799.
  63. Poon, A, Li, Z, Wolfe, GW, Lu, L, Williams, RW, Hayes, NL et al.. Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur. J. Neurosci. 2010;32 (4):523-37. doi: 10.1111/j.1460-9568.2010.07316.x. PubMed PMID:20718853 PubMed Central PMC3382016.
  64. Samaan, G, Yugo, D, Rajagopalan, S, Wall, J, Donnell, R, Goldowitz, D et al.. Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects. Biochem. Biophys. Res. Commun. 2010;400 (1):60-5. doi: 10.1016/j.bbrc.2010.07.142. PubMed PMID:20691664 .
  65. Fyfe, JC, Al-Tamimi, RA, Castellani, RJ, Rosenstein, D, Goldowitz, D, Henthorn, PS et al.. Inherited neuroaxonal dystrophy in dogs causing lethal, fetal-onset motor system dysfunction and cerebellar hypoplasia. J. Comp. Neurol. 2010;518 (18):3771-84. doi: 10.1002/cne.22423. PubMed PMID:20653033 PubMed Central PMC3006439.
  66. Dickson, PE, Rogers, TD, Del Mar, N, Martin, LA, Heck, D, Blaha, CD et al.. Behavioral flexibility in a mouse model of developmental cerebellar Purkinje cell loss. Neurobiol Learn Mem. 2010;94 (2):220-8. doi: 10.1016/j.nlm.2010.05.010. PubMed PMID:20566377 PubMed Central PMC2922405.
  67. Martin, LA, Goldowitz, D, Mittleman, G. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur. J. Neurosci. 2010;31 (3):544-55. doi: 10.1111/j.1460-9568.2009.07073.x. PubMed PMID:20105240 PubMed Central PMC2846709.
  68. Philip, VM, Duvvuru, S, Gomero, B, Ansah, TA, Blaha, CD, Cook, MN et al.. High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes Brain Behav. 2010;9 (2):129-59. doi: 10.1111/j.1601-183X.2009.00540.x. PubMed PMID:19958391 PubMed Central PMC2855868.
  69. Freedman, R, Goldowitz, D. Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia. Prog. Neurobiol. 2010;90 (2):263-75. doi: 10.1016/j.pneurobio.2009.10.008. PubMed PMID:19853005 PubMed Central PMC2829353.
  70. Mathews, TA, Brookshire, BR, Budygin, EA, Hamre, K, Goldowitz, D, Jones, SR et al.. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol. 2009;43 (6):421-31. doi: 10.1016/j.alcohol.2009.04.006. PubMed PMID:19801272 PubMed Central PMC2782517.
  71. Jiao, Y, Cai, C, Kermany, MH, Yan, J, Cai, Q, Miller, D et al.. ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice. Genes Genet. Syst. 2009;84 (3):219-24. doi: 10.1266/ggs.84.219. PubMed PMID:19745570 PubMed Central PMC3155952.
  72. Overall, RW, Kempermann, G, Peirce, J, Lu, L, Goldowitz, D, Gage, FH et al.. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 2009;3 :55. doi: 10.3389/neuro.15.003.2009. PubMed PMID:20582282 PubMed Central PMC2858614.
  73. Jin, N, Chow, CY, Liu, L, Zolov, SN, Bronson, R, Davisson, M et al.. VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 2008;27 (24):3221-34. doi: 10.1038/emboj.2008.248. PubMed PMID:19037259 PubMed Central PMC2600653.
  74. Dragatsis, I, Goldowitz, D, Del Mar, N, Deng, YP, Meade, CA, Liu, L et al.. CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse. Neurobiol. Dis. 2009;33 (3):315-30. doi: 10.1016/j.nbd.2008.10.009. PubMed PMID:19027857 PubMed Central PMC4461140.
  75. Yang, GS, Banks, KG, Bonaguro, RJ, Wilson, G, Dreolini, L, de Leeuw, CN et al.. Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus. Genomics. 2009;93 (3):196-204. doi: 10.1016/j.ygeno.2008.09.014. PubMed PMID:18950699 .
  76. Crusio, WE, Goldowitz, D, Holmes, A, Wolfer, D. Standards for the publication of mouse mutant studies. Genes Brain Behav. 2009;8 (1):1-4. doi: 10.1111/j.1601-183X.2008.00438.x. PubMed PMID:18778401 .
  77. D'Souza, CA, Chopra, V, Varhol, R, Xie, YY, Bohacec, S, Zhao, Y et al.. Identification of a set of genes showing regionally enriched expression in the mouse brain. BMC Neurosci. 2008;9 :66. doi: 10.1186/1471-2202-9-66. PubMed PMID:18625066 PubMed Central PMC2483290.
  78. Matthews, DB, Morrow, AL, O'Buckley, T, Flanigan, TJ, Berry, RB, Cook, MN et al.. Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice. Alcohol. 2008;42 (6):469-76. doi: 10.1016/j.alcohol.2008.05.001. PubMed PMID:18599253 PubMed Central PMC2575102.
  79. Matthews, DB, Chesler, EJ, Cook, MN, Cockroft, J, Philip, VM, Goldowitz, D et al.. Genetic mapping of vocalization to a series of increasing acute footshocks using B6.A consomic and B6.D2 congenic mouse strains. Behav. Genet. 2008;38 (4):417-23. doi: 10.1007/s10519-008-9210-7. PubMed PMID:18535899 PubMed Central PMC2504763.
  80. Mittleman, G, Goldowitz, D, Heck, DH, Blaha, CD. Cerebellar modulation of frontal cortex dopamine efflux in mice: relevance to autism and schizophrenia. Synapse. 2008;62 (7):544-50. doi: 10.1002/syn.20525. PubMed PMID:18435424 PubMed Central PMC3854870.
  81. Reiner, A, Del Mar, N, Deng, YP, Meade, CA, Sun, Z, Goldowitz, D et al.. R6/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice. J. Comp. Neurol. 2007;505 (6):603-29. doi: 10.1002/cne.21515. PubMed PMID:17948889 .
  82. Liu, L, Geisert, EE, Frankfurter, A, Spano, AJ, Jiang, CX, Yue, J et al.. A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein. Genesis. 2007;45 (9):560-9. doi: 10.1002/dvg.20325. PubMed PMID:17868115 PubMed Central PMC2814058.
  83. Hamre, KM, Goldowitz, D, Wilkinson, S, Matthews, DB. Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes. Behav. Neurosci. 2007;121 (4):665-78. doi: 10.1037/0735-7044.121.4.665. PubMed PMID:17663592 .
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