Hayden Lab

Room 3025
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Principal Investigator
+1 (604) 875-3535

Senior Scientist, CMMT, UBC
Canada Research Chair in Human Genetics and Molecular Medicine
University Killam Professor, Department of Medical Genetics, UBC

Betty Nguyen
Room 3004
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
+1 (604) 875-3808
+1 (604) 875-3819
Britt Drogemoller, PhD
890 West 28th Ave.,
Vancouver, BC
V5Z 4H4
Post Doctoral Fellow
Chris  Kay
Room 3004
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
PhD student
+1 604-875-3999
+1 604-875-3840

TRAINEE INFORMATION

Degree sought PhD
Thesis topic Population Genetics and Allele-Specific Silencing of the Huntington Disease Mutation
Grad advisor Dr. Michael Hayden
EDUCATION

University of British Columbia, Vancouver, BC
University of West Florida, Pensacola, FL
Harvey Mudd College, Claremont, CA

RESEARCH INTERESTS

Fine-Mapping of Genetic Loci
Neurodegenerative Disease
Genetic Medicine
Population Genetics
Genetic Epidemiology
Repeat Instability
Genetic and Epigenetic Modifiers

View my Google Scholar profile here

View my full CV here

AWARDS & HONORS

Canadian Institutes of Health Research (CIHR) Doctoral Research Award
Pfizer Ripples of Hope Award Recipient in Mental Health Research
Florida Academic Scholar
Harvey Mudd College Nova Scholar

PUBLICATIONS

Reviews and Invited Reviews

1   Review   Kay C, Skotte NH, Southwell AL, Hayden MR. Personalized gene silencing therapeutics for Huntington disease. Clin. Genet. (2014) PMID 24646433
Journal Articles

1   Kay C, Tirado-Hurtado I, Cornejo-Olivas M, Collins JA, Wright G, Inca-Martinez M, Veliz-Otani D, Ketelaar ME, Slama RA, Ross CJ, Mazzetti P, Hayden MR. The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America. Eur. J. Hum. Genet. (2016) PMID 28000697
2   Kay C, Collins JA, Miedzybrodzka Z, Madore SJ, Gordon ES, Gerry N, Davidson M, Slama RA, Hayden MR. Huntington disease reduced penetrance alleles occur at high frequency in the general population. Neurology (2016) PMID 27335115
3   Kay C, Collins JA, Skotte NH, Southwell AL, Warby SC, Caron NS, Doty CN, Nguyen B, Griguoli A, Ross CJ, Squitieri F, Hayden MR. Huntingtin Haplotypes Provide Prioritized Target Panels for Allele Specific Silencing in Huntington Disease Patients of European Ancestry. Mol. Ther. (2015) PMID 26201449
4   Bečanović K, Nørremølle A, Neal SJ, Kay C, Collins JA, Arenillas D, Lilja T, Gaudenzi G, Manoharan S, Doty CN, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, De Souza RA, , Tabrizi SJ, Hermanson O, Langbehn DR, Hayden MR, Wasserman WW, Leavitt BR. A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease. Nat. Neurosci. (2015) PMID 25938884
5   Semaka A, Kay C, Belfroid RD, Bijlsma EK, Losekoot M, van Langen IM, van Maarle MC, Oosterloo M, Hayden MR, van Belzen MJ. A new mutation for Huntington disease following maternal transmission of an intermediate allele. Eur J Med Genet 58(1):28-30. (2015) PMID 25464109
6   Semaka A, Kay C, Doty CN, Collins JA, Tam N, Hayden MR. High frequency of intermediate alleles on huntington disease-associated haplotypes in British Columbia’s general population. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2013) PMID 24038799
7   Semaka A, Kay C, Doty C, Collins JA, Bijlsma EK, Richards F, Goldberg YP, Hayden MR. CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease. J. Med. Genet. 50(10):696-703. (2013) PMID 23896435
8   Baine FK, Kay C, Ketelaar ME, Collins JA, Semaka A, Doty CN, Krause A, Greenberg LJ, Hayden MR. Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes. Eur. J. Hum. Genet. 21(10):1120-7. (2013) PMID 23463025
Invited Submissions, Books, Chapters, Letters, and Editorials

1   Chapter   Kay C, Fisher E, Hayden MR. Epidemiology. In: Huntington’s Disease, 4th Edition Oxford University Press (2014)

Daphne Cheung
Room 3028
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
604-875-3817
604-875-3819
Dawn Ng
Room 3026
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Executive Coordinator
+1 (604) 875-3535
+1 (604) 875-3819
Fanny Lemarie
Room 3004
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Post doctoral fellow
+1 (604) 875-3809
+1 (604) 875-3840
Galen Wright, PhD
950 West 28th Ave, Vancouver, BC
V5Z 4H4
Post Doctoral Fellow
+1 (604) 875-2000 ext 6217
Hailey Findlay Black
Room 3003

Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
+1 (604) 875-3817
+1 (604) 875-3840
Huijun Mark Wang
Room 3003
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
+1 (604) 875-3825
+1 (604) 875-3840
Jennifer A. Collins
Room 3008
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research coordinator/HD BioBank Coordinator
+1 (604) 875-3999
+1 (604) 875-3819
Lisa Anderson
Room 2004
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research Assistant
+1 (604) 875-3817
+1 (604) 875-3819
Lorenzo Casal
Room 3003
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
604-875-3817
604-875-3819
Louisa Dal Cengio
Room 3003
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research Assistant
+1 (604) 875-3817
+1 (604) 875-3819
Mahsa Amirabbasi
Centre for Molecular Medicine and Therapeutics
Room 3007
950 West 28th Ave
Vancouver, BC
V5Z 4H4 Canada
Lab manager
604-875-3811
604-875-3819
Mandi Schmidt
Room 3004
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
PhD student
+1 (604) 875-3809
+1 (604) 875-3840
Meenalochani Sivasubramanian
Room 3003
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Post doctoral fellow
+1 (604) 875-3817
+1 (604) 875-3840
Nicholas Caron, PhD
Room 3003

Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canad
Post doctotral fellow
604-875-2000 ext 5620
604-875-3819
Qingwen Xia
Room 3002
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
+1 (604) 875-3825
+1 (604) 875-3840
Robert  Tiszolczi
Room 3109
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Finance manager
+1 (604)-875-3844
+1 (604) 875-3819
Robert Xie
Room 3002
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
+1 (604) 875-3808
+1 (604) 875-3840
Seetha Kumaran
Room 3024
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research manager
+1 (604) 875-3823
+1 (604) 875-3819
Xiaofan Qiu
Room 3003
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
+1 (604) 875-3817
+1 (604) 875-3840
Yun Ko
Room 3003
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Research assistant
+1 (604) 875-3817
+1 (604) 875-3840