Liam Brunham
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FACULTY & STAFF DIRECTORY
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Liam Brunham
MD, PhD
Resident, Internal Medicine
Postdoctoral Research Fellow
Group Hayden Lab
Email
Direct line +1 (604) 875-3825
Fax +1 (604) 875-3819

ADDITIONAL CONTACT INFORMATION

Location Room 3002
 
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada

EDUCATION

MD, PhD, University of British Columbia, 2008
BSc (with distinction), University of Manitoba, 2001

RESEARCH INTERESTS

  • Genetics of HDL metabolism and atherosclerosis
  • Conditional gene targeting
  • Tissue specific functions of ABCA1
  • Genetics of complex diseases
  • SNP association studies
  • Genetics of susceptibility and resistance to infectious diseases
  • Comparative genome analysis

AWARDS & HONORS

  • Pacific Blue Cross Medical Entrance Scholarship, 2001
  • CIHR MD PhD Studentship, 2002
  • BC Science Council GREAT Award, 2002
  • Lowell Glasgow Student Research Award, 2003
  • Michael Smith Foundation for Health Research Doctoral Award, 2003
  • Canadian Society for Clinical Investigation Young Investigators Award, 2003
  • Gordon Research Conference on Lipoprotein Metabolism Outstanding Poster Award, 2004
  • American Heart Association ATVB Young Investigator Award, 2005
  • Gordon Conference on Atherosclerosis First Prize, Student Poster Competition, 2005
  • CFRI Outstanding Achievement by a Doctoral Student, 2007
  • Governor General's Gold Medal, 2008

Publications

Reviews and Invited Reviews

1   Review   Brunham LR, Kruit JK, Verchere CB, Hayden MR. Cholesterol in islet dysfunction and type 2 diabetes. J. Clin. Invest. 118(2):403-8. (2008) PMID 18246189

Journal Articles

1   Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ, Rodrigues B, Johnson JD, Parks JS, Verchere CB, Hayden MR. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat. Med. 13(3):340-7. (2007) PMID 17322896
2   Brunham LR, Kruit JK, Iqbal J, Fievet C, Timmins JM, Pape TD, Coburn BA, Bissada N, Staels B, Groen AK, Hussain MM, Parks JS, Kuipers F, Hayden MR. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J. Clin. Invest. 116(4):1052-62. (2006) PMID 16543947
3   Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene. PLoS Genet. 1(6):e83. (2005) PMID 16429166
4   Timmins JM, Lee JY, Boudyguina E, Kluckman KD, Brunham LR, Mulya A, Gebre AK, Coutinho JM, Colvin PL, Smith TL, Hayden MR, Maeda N, Parks JS. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J. Clin. Invest. 115(5):1333-42. (2005) PMID 15841208
5   Brunham L. A common mutation in IVD associated with asymptomatic isovaleric acidemia: implications for newborn screening. Clin Genet 67(3):226-7. (2005)
6   Guan JZ, Tamasawa N, Brunham LR, Matsui J, Murakami H, Suda T, Ochiai S, Tsutsui M, Kudou K, Satoh K, Hayden MR. A case of Tangier disease with a novel mutation in the C-terminal region of ATP-binding cassette transporter A1. Am. J. Med. Genet. A 130A(4):398-401. (2004) PMID 15384103
7   Singaraja RR, Brunham LR, Visscher H, Kastelein JJ, Hayden MR. Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene. Arterioscler. Thromb. Vasc. Biol. 23(8):1322-32. (2003) PMID 12763760
8   Wellington CL, Brunham LR, Zhou S, Singaraja RR, Visscher H, Gelfer A, Ross C, James E, Liu G, Huber MT, Yang YZ, Parks RJ, Groen A, Fruchart-Najib J, Hayden MR. Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1. J. Lipid Res. 44(8):1470-80. (2003) PMID 12730295
9   Brunham LR. What we have learned from the DNA sequences of human chromosomes 21 and 22 Clinical Genetics 58(3):166. (2000)