Luis del Peso
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FACULTY & STAFF DIRECTORY
Profile photo
Luis del Peso
PhD
Associate Professor
Department of Biochemistry
Universidad Autonoma de Madrid
Visiting Professor
Group Wasserman Lab
Email
Direct line
Fax +1 (604) 875-3819

ADDITIONAL CONTACT INFORMATION

Location Room 3109, Wasserman Lab
 
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada

EDUCATION

  • M.Sc./Bioinformatics and computational biology/Universidad Complutense(Madrid, ES)/2005
  • Ph.D.Biochemistry and Molecular Biology/Universidad Autonoma(Madrid, ES)/1996
  • B.Sc./Biochemistry and Molecular Biology/Universidad Autonoma(Madrid, ES)/1991

RESEARCH INTERESTS

  • Regulation of gene expression
  • Metabolic adaptations to hypoxia
  • Mediators of angiogenesis in response to hypoxia
  • Role of hypoxia in cancer and COPD
  • Genetics of variations in non-coding sequences
  • Evolution of the oxygen-sensing machinery

COLLABORATORS

M.O. Landázuri (HUP, Madrid, ES) J. Guinovart (IRB, Barcelona, ES) P.S. Yan (Columbus U., Ohio, US) Z. Trajanoski (U of Tech, Graz, AU) L. Montoliu (CNB; Madrid, ES) J.L Gomez-Skarmeta (CABD, Sevilla, ES) B. Jimenez (UAM, Madrid,ES) A. Harris (U. Oxford, Oxford, UK) W.W. Wasserman (UBC, Vancouver, CA)

PROFESSIONAL ACTIVITIES

  • Associate Professor/Departamento de Bioquímica, Universidad Autónoma de Madrid (Madrid, Spain)/2008-/Regulation of gene expression by hypoxia.
  • Assistant Professor/Departamento de Bioquímica, Universidad Autónoma de Madrid (Madrid, Spain)/2003-2008/Regulation of gene expression by hypoxia.
  • Researcher (“Investigador Ramón y Cajal”)/Departamento de Medicina, Universidad Autónoma de Madrid (Madrid, Spain)/2001-2003. Regulation of gene expression by hypoxia.
  • Researcher (“Investigador FIS”)/Hospital de la Princesa (Madrid, Spain)/1999-2001/Regulation of gene expression by hypoxia.
  • Research scholar/Universidad de Michigan (Ann Arbor, USA)/1996-1999/Regulation of apoptosis. Mentor: Dr. Gabriel Nuñez.
  • PhD Student/Instituto Investigaciones Biomédicas (Madrid, Spain)/1991-1996/Signaling by Ras proteins. Mentor: Dr. Juan Carlos Lacal

Publications

Journal Articles

1   Martinez-Poveda B, Gomez V, Alcaide-German M, Perruca S, Vazquez S, Alba LE, Casanovas O, Garcia-Bermejo ML, Peso L, Jimenez B. Non-invasive monitoring of hypoxia-inducible factor activation by optical imaging during antiangiogenic treatment in a xenograft model of ovarian carcinoma. Int. J. Oncol. 39(3):543-52. (2011) PMID 21667025
2   Pescador N, Villar D, Cifuentes D, Garcia-Rocha M, Ortiz-Barahona A, Vazquez S, Ordoñez A, Cuevas Y, Saez-Morales D, Garcia-Bermejo ML, Landazuri MO, Guinovart J, del Peso L. Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. PLoS ONE 5(3):e9644. (2010) PMID 20300197
3   Ortiz-Barahona A, Villar D, Pescador N, Amigo J, del Peso L. Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction. Nucleic Acids Res. 38(7):2332-45. (2010) PMID 20061373
4   Aceves-Luquero CI, Agarwal A, Callejas-Valera JL, Arias-González L, Esparís-Ogando A, del Peso Ovalle L, Bellón-Echeverria I, de la Cruz-Morcillo MA, Galán Moya EM, Moreno Gimeno I, Gómez JC, Deininger MW, Pandiella A, Sánchez Prieto R. ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy. PLoS ONE 4(7):e6124. (2009) PMID 19568437
5   Alcaide-German ML, Vara-Vega A, Garcia-Fernandez LF, Landazuri MO, del Peso L. A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery. BMC Cell Biol. 9:18. (2008) PMID 18402654
6   Villar D, Vara-Vega A, Landázuri MO, Del Peso L. Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains. Biochem. J. 408(2):231-40. (2007) PMID 17725546
7   Olmos G, Conde I, Arenas I, Del Peso L, Castellanos C, Landazuri MO, Lucio-Cazana J. Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. Cell. Signal. 19(10):2098-105. (2007) PMID 17658243
8   Calzada MJ, del Peso L. Hypoxia-inducible factors and cancer. Clin Transl Oncol 9(5):278-89. (2007) PMID 17525038
9   Landázuri MO, Vara-Vega A, Vitón M, Cuevas Y, del Peso L. Analysis of HIF-prolyl hydroxylases binding to substrates. Biochem. Biophys. Res. Commun. 351(2):313-20. (2006) PMID 17069766
10   Pescador N, Cuevas Y, Naranjo S, Alcaide M, Villar D, Landázuri MO, Del Peso L. Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem. J. 390(Pt 1):189-97. (2005) PMID 15823097
11   Cuevas Y, Hernández-Alcoceba R, Aragones J, Naranjo-Suárez S, Castellanos MC, Esteban MA, Martín-Puig S, Landazuri MO, del Peso L. Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cancer Res. 63(20):6877-84. (2003) PMID 14583486
12   del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri MO. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J. Biol. Chem. 278(49):48690-5. (2003) PMID 14506252
13   Naranjo-Suárez S, Castellanos MC, Alvarez-Tejado M, Vara A, Landázuri MO, del Peso L. Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. J. Biol. Chem. 278(34):31895-901. (2003) PMID 12805361
14   Lucas L, Penalva V, Ramírez de Molina A, Del Peso L, Lacal JC. Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1. Int. J. Oncol. 21(3):477-85. (2002) PMID 12168089
15   Alvarez-Tejado M, Alfranca A, Aragonés J, Vara A, Landázuri MO, del Peso L. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J. Biol. Chem. 277(16):13508-17. (2002) PMID 11815624
16   Alvarez-Tejado M, Naranjo-Suarez S, Jiménez C, Carrera AC, Landázuri MO, del Peso L. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J. Biol. Chem. 276(25):22368-74. (2001) PMID 11294857
17   Hernández-Alcoceba R, del Peso L, Lacal JC. The Ras family of GTPases in cancer cell invasion. Cell. Mol. Life Sci. 57(1):65-76. (2000) PMID 10949581
18   Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Núñez G. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J. Biol. Chem. 275(36):27823-31. (2000) PMID 10880512
19   del Peso L, Gonzalez VM, Inohara N, Ellis RE, Núñez G. Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. J. Biol. Chem. 275(35):27205-11. (2000) PMID 10846174
20   Lucas L, del Peso L, Rodríguez P, Penalva V, Lacal JC. Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor. Oncogene 19(3):431-7. (2000) PMID 10656691
21   del Peso L, González VM, Hernández R, Barr FG, Núñez G. Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt. Oncogene 18(51):7328-33. (1999) PMID 10602488
22   Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J. Biol. Chem. 274(21):14560-7. (1999) PMID 10329646
23   del Peso L, González VM, Núñez G. Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. J. Biol. Chem. 273(50):33495-500. (1998) PMID 9837929
24   Nuñez G, del Peso L. Linking extracellular survival signals and the apoptotic machinery. Curr. Opin. Neurobiol. 8(5):613-8. (1998) PMID 9811624
25   Esteve P, Embade N, Perona R, Jiménez B, del Peso L, León J, Arends M, Miki T, Lacal JC. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene 17(14):1855-69. (1998) PMID 9778052
26   Inohara N, del Peso L, Koseki T, Chen S, Núñez G. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J. Biol. Chem. 273(20):12296-300. (1998) PMID 9575181
27   del Peso L, Hernández-Alcoceba R, Embade N, Carnero A, Esteve P, Paje C, Lacal JC. Rho proteins induce metastatic properties in vivo. Oncogene 15(25):3047-57. (1997) PMID 9444953
28   del Peso L, González-García M, Page C, Herrera R, Nuñez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278(5338):687-9. (1997) PMID 9381178
29   del Peso L, Lucas L, Esteve P, Lacal JC. Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways. Biochem. J. 322 ( Pt 2):519-28. (1997) PMID 9065772
30   del Peso L, Hernández R, Esteve P, Lacal JC. Activation of phospholipase D by ras proteins is independent of protein kinase C. J. Cell. Biochem. 61(4):599-608. (1996) PMID 8806084
31   Esteve P, del Peso L, Lacal JC. Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis. Oncogene 11(12):2657-65. (1995) PMID 8545123
32   Jiménez B, del Peso L, Montaner S, Esteve P, Lacal JC. Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation. J. Cell. Biochem. 57(1):141-9. (1995) PMID 7721953
33   Carnero A, Cuadrado A, del Peso L, Lacal JC. Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells. Oncogene 9(5):1387-95. (1994) PMID 8152799