Our Story

Our Story

In 1992, Dr. Michael Hayden envisioned a world-class venue for advanced genetic research employing the best and brightest minds from around the world. The ideal setting, he believed, would be a new type of 'research centre without walls'—one that is affiliated with a leading research university, teaching hospital and industry partner, and linked globally to other prominent scientific institutions.

return to topFOUNDING PARTNERS

Four founding partners played a critical role in the creation of CMMT: Merck Frosst Canada Inc., the University of British Columbia, British Columbia’s Children’s Hospital, and the Government of British Columbia.

However, it was Merck Frosst’s contribution that turned the dream into a reality. In 1993, Canada’s preeminent pharmaceutical company committed $15 million to represent the largest extramural research commitment in Canada by a pharmaceutical company and also the largest in the history of their company globally. Merck later committed an additional $15 million to support the Centre, as part of the renewal. This partnership, which was successfully completed in October 2006, has helped attract a high caliber of researchers worldwide and over $70 million of external sources of R&D funding into British Columbia.

return to topA DECADE OF DISCOVERY

When the Centre moved from its initial quarters at the UBC Campus to the new CMMT building situated at the Hospital site in the spring of 1998, it was already a thriving UBC-approved research environment. As architects worked to generate the optimal physical environment for cutting-edge research, scientific papers were adorning the covers of leading scientific journals and researchers were contributing to a greater understanding of basic life processes and the impact on human illnesses such as Huntington disease and lipid abnormalities.

With 5 staff in 1995, the Centre began working to identify promising younger scientists that would share the same mission—to pursue excellence in genetic discovery for the improvement of child and family health. Between 1997 and 2002, the CMMT recruited six outstanding investigators from prestigious institutions including the US-based Jackson Laboratory, Whitehead Institute and Karolinska Institute in Sweden. Today, CMMT employs approximately 190 staff and researchers with a nearly seven times increase in funding since 1995. Over the past decade, the CMMT has emerged as a major force for change and innovation in genetics research.

return to topTIMELINE

Since the announcement of Merck Frosst's commitment to fund CMMT in September 1992, there have been a number of significant milestones in the history of the CMMT. Research advances are highlighted in bold text.

YearMilestones and advances in research
1992Dr. Michael Hayden secures a $15 million investment from Merck Frosst Canada to establish the Centre for Molecular Medicine and Therapeutics (CMMT) in Vancouver
1993We become the first "centre" of the Faculty of Medicine approved by the UBC Senate
1993The province of British Columbia pledges $9 million to build a new building for CMMT
1998Our faculty and staff relocate to the new building at Oak and 28th Avenue
1998Our Transgenic Core Facility is established
1999ABCA1, a key regulator of HDL levels in humans, is discovered
1999Our CMMT/CFRI Scientific Stores Core Facility is established
2000Our CMMT/CGDN DNA Sequencing Core Facility is established
2001Merck Frosst Canada renews its funding of the CMMT for an additional five years
2003LPL deficiency is cured in animal models, which leads to gene therapy trials in humans in 2005 (Phase I/II) and 2007 (Phase III)
2003Our CMMT/CFRI Bioanalyzer Core Facility is established
2004The open-access JASPAR database is released by our bioinformatics group and becomes a fundamental resource for studying gene regulation
2005A national Genotype-Specific Approaches to Therapy in Childhood (GATC) Project is initiated to identify genetic causes of severe adverse drug reactions (ADR) in children
2005Our gene networks analysis algorithm is published
2005Our Transgenics Core Facility is enhanced and expanded, doubling its initial capacity
2005UBC signs a commitment to create a $7.5 million endowment for the CMMT
2006Our Genotyping and Gene Expression Core Facility is established
2006Huntington's disease is prevented in mice
2006The international Pleiades Promoter Project is initiated to develop genomic resources to advance therapies for brain disorders
2006The genetic cause of codeine-induced ADR causing infant death is identified
2006A new palmitoyl transferase that promotes protein folding and transport is found
2006BC Children's Hospital Foundation establishes a $15 million endowment for the CMMT
2007The contribution of cholesterol to diabetes is elucidated
2007Software for identifying DNA changes that alter the regulation of genes is created
2008A new gene associated with Bipolar disorder is identified
2008Genomic analysis of endosomal transport machinery is completed
2008The Pharmacogenomic Network for Drug Safety funded by the Canadian Institutes for Health Research and the Canadian Foundation for Innovation is initiated
2008Genetic variants predictive of severe deafness in children receiving cisplatin chemotherapy are identified